Adsorption method, adsorption separation method, and drug delivery carrier

Patent metadata

Field	Value
Publication number	US-9795896-B2
Application number	US-201514658352-A
Country	US
Kind code	B2
Filing date	Mar 16, 2015
Priority date	Sep 18, 2012
Publication date	Oct 24, 2017
Grant date	Oct 24, 2017

Abstract

An adsorption method adsorbs a substance by using a tube-shaped apatite crystal. The apatite crystal may be a monocrystal given by a general formula M 2 5 (PO 4 ) 3 X (M 2 denotes at least one element selected from the group consisting of divalent alkali earth metal and Eu, and X denotes at least one element or molecule selected from the group consisting of halogen element and OH). The outer form of the apatite crystal may be a hexagonal prism in which the aperture of a hole formed on a top surface or bottom surface of the hexagonal prism may be hexagonal.

First claim

What is claimed is:

1. An adsorption method for adsorbing a substance, comprising:
adsorbing the substance on a tube-shaped apatite crystal;
wherein the tube-shaped apatite crystal is a monocrystal given by general formula M 2 5 (PO 4 ) 3 X, whereby M 2 represents at least one element selected from the group consisting of divalent alkali earth metals and Eu, and whereby X represents at least one element selected from the group consisting of halogen elements,
wherein an outer form of the apatite crystal is a hexagonal prism in which an aperture of a hole formed on a top surface or bottom surface of the hexagonal prism is hexagonal, and
wherein at least one interior lateral surface of an interior wall of the hole is comprised of one monocrystal.

2. The adsorption method according to claim 1 , wherein an inner diameter of the tube-shaped apatite crystal is 10 nm to 10 μm.

3. An adsorption separation method comprising:
adsorbing protein or amino acid on a tube-shaped apatite crystal; and
causing the apatite crystal on which the protein or amino acid is adsorbed to contact an aqueous chloride solution, and
selectively isolating the adsorbed protein or amino acid;
wherein the tube-shaped apatite crystal is a monocrystal given by a general formula M 2 5 (PO 4 ) 3 X, whereby M 2 represents at least one element selected from the group consisting of divalent alkali earth metals and Eu, and whereby X represents at least one element selected from the group consisting of halogen elements,
wherein an outer form of the apatite crystal is a hexagonal prism in which an aperture of a hole formed on a top surface or bottom surface of the hexagonal prism is hexagonal, and
wherein at least one interior lateral surface of an interior wall of the hole is comprised of one monocrystal.

4. A drug delivery carrier comprising a tube-shaped apatite crystal and a drug carried by the tube-shaped apatite crystal;
wherein the tube-shaped apatite crystal is a monocrystal given by a general formula M 2 5 (PO 4 ) 3 X, whereby M 2 represents at least one element selected from the group consisting of divalent alkali earth metals and Eu, and whereby X represents at least one element selected from the group consisting of halogen elements,
wherein an outer form of the apatite crystal is a hexagonal prism in which an aperture of a hole formed on a top surface or bottom surface of the hexagonal prism is hexagonal, and
wherein at least one interior lateral surface of an interior wall of the hole is comprised of one monocrystal.

5. The drug delivery carrier according to claim 4 , wherein a drug is carried inside the tube-shaped apatite crystal.

6. The drug delivery carrier according to claim 4 , wherein an inner diameter of the tube-shaped apatite crystal is 10 nm to 50 μm.

7. An adsorption method according to claim 1 , comprising:
filing a column with the tube-shaped apatite crystal; and
passing a fluid containing the substance through the column.

Assignees

• Koito Mfg Co Ltd

Inventors

• Enomoto Kiminori
• Daicho Hisayoshi
• Shinomiya Yu

Classifications

• B01J20/3078

  Thermal treatment, e.g. calcining or pyrolizing · CPC title

• B01J20/28004

  Sorbent size or size distribution, e.g. particle size · CPC title

• B01J20/28042

  Shaped bodies; Monolithic structures · CPC title

• B01J20/048 Primary

  containing phosphorus, e.g. phosphates, apatites, hydroxyapatites · CPC title

• A61K9/70

  Web, sheet or filament bases {; Films; Fibres of the matrix type containing drug (hollow drug-filled fibres A61K9/0092)} · CPC title