Stem cell factor inhibitor

Patent metadata

Field	Value
Publication number	US-9790272-B2
Application number	US-201615058918-A
Country	US
Kind code	B2
Filing date	Mar 2, 2016
Priority date	Jan 10, 2011
Publication date	Oct 17, 2017
Grant date	Oct 17, 2017

Abstract

Provided herein are methods, compositions, and uses relating to inhibitors of stem cell factor. For example, provided herein are antibodies targeting stem cell factor and methods for treating fibrotic and tissue remodeling diseases.

First claim

We claim:

1. A method of treating a subject, the method comprising administering to the subject an anti-stem cell factor antibody that specifically binds to stem cell factor isoform b relative to stem cell factor isoform a or an antigen-binding antibody fragment that specifically binds to stem cell factor isoform b relative to stem cell factor isoform a.

2. The method of claim 1 wherein the antibody or the antigen-binding antibody fragment specifically binds to a protein comprising an amino acid sequence provided by SEQ ID NO: 4 or an antibody-binding fragment thereof.

3. The method of claim 1 wherein the antibody is a monoclonal antibody or the antigen-binding antibody fragment is a fragment of a monoclonal antibody.

4. The method of claim 1 wherein the antibody is a polyclonal antibody.

5. The method of claim 1 wherein the antibody is a humanized antibody or chimeric antibody or the antigen-binding antibody fragment is a fragment of a humanized or a chimeric antibody.

6. The method of claim 1 wherein the antibody or antigen-binding antibody fragment is a Fab, a Fab′, a F(ab′), a Fv fragment, a scFv fragment, or a linear antibody.

7. The method of claim 1 comprising administering the anti-stem cell factor antibody or antigen-binding antibody fragment in a physiologically appropriate solution to the subject.

8. The method of claim 1 comprising administering the anti-stem cell factor antibody or antigen-binding antibody fragment into an airway of a subject.

9. The method of claim 1 wherein the subject has a fibrosis or a tissue remodeling disease.

10. The method of claim 1 wherein the subject has idiopathic pulmonary fibrosis, chronic obstructive pulmonary disease, acute respiratory distress syndrome, cystic fibrosis, peribronchial fibrosis, hypersensitivity pneumonitis, asthma, sclerodoma, inflammation, liver cirrhosis, renal fibrosis, parenchymal fibrosis, endomyocardial fibrosis, mediastinal fibrosis, nodular subepidermal fibrosis, fibrous histiocytoma, fibrothorax, hepatic fibrosis, fibromyalgia, gingival fibrosis, or radiation-induced fibrosis.

11. The method of claim 1 wherein the subject is in need of inhibition of SCF.

12. The method of claim 1 comprising administering the anti-stem cell factor antibody or antigen-binding antibody fragment by a topical, intraocular, parenteral, oral, buccal, intranasal, intravenous, intramuscular, or subcutaneous route.

13. The method of claim 1 comprising administering a pharmaceutically effective amount of the anti-stem cell factor antibody or antigen-binding antibody fragment to the subject.

14. The method of claim 1 comprising administering a plurality of doses of the anti-stem cell factor antibody or antigen-binding antibody fragment to the subject.

15. The method of claim 1 comprising administering the anti-stem cell factor antibody or antigen-binding antibody fragment in a physiologically appropriate solution comprising a pharmaceutically acceptable carrier, diluent, or excipient.

Assignees

• Univ Michigan Regents

Inventors

• Lukacs Nicholas W
• Dolgachev Vladislav A
• Kunkel Steven L
• Hogaboam Cory M
• Phan Sem H

Classifications

• A61P39/00

  General protective or antinoxious agents · CPC title

• A61P9/00

  Drugs for disorders of the cardiovascular system · CPC title

• A61P7/04

  Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents · CPC title

• A61P35/00

  Antineoplastic agents · CPC title

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title