Phenoxyethyl cyclic amine derivatives and their activity as EP4 receptor modulators

US9776964B2 · US · B2

Patent metadata
FieldValue
Publication numberUS-9776964-B2
Application numberUS-201415030888-A
CountryUS
Kind codeB2
Filing dateDec 11, 2014
Priority dateDec 17, 2013
Publication dateOct 3, 2017
Grant dateOct 3, 2017

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  1. Title

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  2. Abstract

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  3. Assignees and inventors

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  4. Key dates

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  5. First independent claim

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  6. CPC / IPC classifications

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  7. Citations and related patents

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Abstract

Official abstract text for this publication.

The present invention provides a compound of the Formula (I): wherein X, R, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , and R 9 are as defined herein, or a pharmaceutically acceptable salt thereof.

First claim

Opening claim text (preview).

We claim: 1. A compound of the formula: wherein X is: R is H, methyl, or ethyl; R 1 is methyl, when R 2 is H, and R 1 is H when R 2 is methyl; R 3 is H or F; R 4 is H, F, or methyl; R 5 is OH, methyl, methoxy, or F; and R 6 is H when R 7 is OH, and R 6 is F when R 7 is F; or a pharmaceutically acceptable salt thereof. 2. The compound or salt according to claim 1 wherein R is methyl. 3. The compound or salt according to claim 2 wherein R 4 is F and R 5 is F. 4. The compound or salt according to claim 2 wherein R 4 is methyl and R 5 is methyl. 5. The compound or salt according to claim 1 wherein X is: 6. The compound or salt according to claim 1 wherein X is: 7. A pharmaceutical composition, comprising a compound or a pharmaceutically acceptable salt thereof according to claim 1 with one or more pharmaceutically acceptable carriers, diluents, or excipients.

Assignees

Inventors

Classifications

  • Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

  • Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] · CPC title

  • Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals · CPC title

  • Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen · CPC title

  • C07D211/60Primary

    Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals · CPC title

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Frequently asked questions

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What does patent US9776964B2 cover?
The present invention provides a compound of the Formula (I): wherein X, R, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , and R 9 are as defined herein, or a pharmaceutically acceptable salt thereof.
Who is the assignee on this patent?
Lilly Co Eli
What technology area does this patent fall under?
Primary CPC classification C07D211/60. Mapped technology areas include Chemistry & Metallurgy.
When was this patent published?
Publication date Tue Oct 03 2017 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
What related patents are in patentsdb?
We list 4 related publications on this page (citations in our corpus or others sharing the same primary CPC).