Phenoxyethyl piperidine compounds

Patent metadata

Field	Value
Publication number	US-9402838-B2
Application number	US-201514595350-A
Country	US
Kind code	B2
Filing date	Jan 13, 2015
Priority date	Jun 29, 2012
Publication date	Aug 2, 2016
Grant date	Aug 2, 2016

Abstract

The present invention provides a compound of the Formula II:

wherein X is:

R 1 is H, —CN, or F;
R 2 is H or methyl;
R 3 is H; and
R 4 is H, methyl, or ethyl; or
R 3 and R 4 joined together form a cyclopropyl ring;
or a pharmaceutically acceptable salt thereof.

First claim

We claim:

1. A pharmaceutical composition, comprising a compound of the formula:

wherein X is:

R 1 is H, —CN, or F;
R 2 is H or methyl;
R 3 is H; and
R 4 is H, methyl, or ethyl; or
R 3 and R 4 joined together form a cyclopropyl ring;
or a pharmaceutically acceptable salt thereof, in combination with one or more pharmaceutically acceptable carriers, diluents, or excipients.

2. The pharmaceutical composition according to claim 1 wherein the compound is:

or a pharmaceutically acceptable salt thereof.

3. The pharmaceutical composition according to claim 2 wherein the compound is:

or a pharmaceutically acceptable salt thereof.

4. The pharmaceutical composition according to claim 3 wherein the compound is:

Assignees

• Lilly Co Eli

Inventors

• Schiffler Matthew Allen
• York Jeremy Schulenburg

Classifications

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P29/00

  Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] · CPC title

• A61P19/00

  Drugs for skeletal disorders · CPC title

• A61P19/02

  for joint disorders, e.g. arthritis, arthrosis · CPC title

• A61K45/06

  Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca · CPC title