Temperature insensitive in vivo analyte devices, methods and systems

Patent metadata

Field	Value
Publication number	US-9775549-B2
Application number	US-201514737082-A
Country	US
Kind code	B2
Filing date	Jun 11, 2015
Priority date	Aug 15, 2014
Publication date	Oct 3, 2017
Grant date	Oct 3, 2017

Abstract

Disclosed herein are membrane structures for use in analyte sensors, where the membrane structures exhibit low temperature sensitivity.

First claim

That which is claimed is:

1. A membrane structure comprising:
an enzyme layer; and
a membrane disposed proximate the enzyme layer, wherein the membrane comprises:
a polymer comprising a heterocyclic nitrogen containing component; and
a monoamine polyetheramine component that is covalently bonded to the nitrogen of the heterocyclic nitrogen containing component of the polymer.

2. The membrane structure according to claim 1 , wherein the heterocyclic nitrogen containing component comprising a heteroaromatic ring system.

3. The membrane structure of claim 1 , wherein the polymer comprises a heterocyclic nitrogen containing component is a poly(4-vinylpyridine-co-styrene) polymer.

4. The membrane structure of claim 3 , wherein the poly(4-vinylpyridine-co-styrene) polymer comprises a compound of the formula:

wherein x and y are each positive integers.

5. The membrane structure of claim 4 , wherein the ratio of x and y is from 1:1 and 5:1.

6. The membrane structure of claim 1 , wherein the monoamine polyetheramine component comprises a polyethylene oxide component and polypropylene oxide component.

7. The membrane structure of claim 6 , wherein the molar ratio of the polypropylene oxide component and polyethylene oxide component is 1:35 to 35:1.

8. The membrane structure of claim 1 , wherein the monoamine polyetheramine component has a molecular weight of 500 daltons to 5000 daltons.

9. The membrane structure of claim 1 , wherein the monoamine polyetheramine component comprises a compound of the formula:

wherein n and m are each positive integers.

10. The membrane structure of claim 1 , wherein the membrane is disposed on the enzyme layer.

Assignees

• Abbott Diabetes Care Inc

Inventors

• Ouyang Tianmei
• Feldman Benjamin J
• Hoss Udo
• Bommakanti Balasubrahmanya S
• Sandhu Gurinder

Classifications

• A61B5/14532

  for measuring glucose, e.g. by tissue impedance measurement · CPC title

• A61B5/686

  Permanently implanted devices, e.g. pacemakers, other stimulators, biochips (A61B5/6861 takes precedence) · CPC title

• A61B5/14865 Primary

  invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors · CPC title