Analyte sensors having a membrane with low temperature sensitivity

Patent metadata

Field	Value
Publication number	US-9380965-B2
Application number	US-201113332103-A
Country	US
Kind code	B2
Filing date	Dec 20, 2011
Priority date	May 20, 2011
Publication date	Jul 5, 2016
Grant date	Jul 5, 2016

Abstract

Embodiments of the present disclosure relate to analyte determining methods and devices (e.g., electrochemical analyte monitoring systems) that have a membrane with low temperature sensitivity. The sensing layer is disposed on a working electrode of in vivo and/or in vitro analyte sensors, e.g., continuous and/or automatic in vivo monitoring using analyte sensors and/or test strips. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring.

First claim

That which is claimed is:

1. An analyte sensor comprising:
a first electrode, a second electrode, and a sensing layer; and
a membrane disposed on the sensing layer, wherein the membrane comprises a poly(4-vinylpyridine)-co-polystyrene polymer and an epoxide-polyether-epoxide crosslinker of the formula:

wherein
m, n and o are each independently positive integers,
R′ and R″ are each a linking group, and
EO is ethylene oxide and PO is propylene oxide.

2. The analyte sensor of claim 1 , wherein the polymer comprises a compound of the formula:

wherein x and y are each positive integers and the ratio of x to y is 1:1.

3. The analyte sensor of claim 1 , wherein the membrane comprises a compound of the formula:

wherein
x and y are each positive integers,
m, n and o are each independently positive integers,
R′ and R″ are each a linking group, and
EO is ethylene oxide and PO is propylene oxide.

4. The analyte sensor of claim 1 , wherein the analyte sensor is configured such that a signal from the analyte sensor changes 5%/° C. or less over a range of temperatures.

5. The analyte sensor of claim 1 , wherein at least a portion of the analyte sensor is adapted to be subcutaneously positioned in a subject.

6. The analyte sensor of claim 1 , wherein the membrane is configured to limit flux of analyte to the sensing layer.

7. The analyte sensor of claim 1 , wherein the sensing layer comprises a glucose-responsive enzyme and a redox mediator.

8. The analyte sensor of claim 7 , wherein the glucose-responsive enzyme comprises glucose oxidase, and the redox mediator comprises a ruthenium-containing complex or an osmium-containing complex.

9. The analyte sensor of claim 7 , wherein the analyte sensor is an in vivo glucose sensor.

Assignees

• Ouyang Tianmei
• Liu Zenghe
• Goti Yohannes
• Feldman Benjamin J
• Hoss Udo
• Abbott Diabetes Care Inc

Inventors

• Ouyang Tianmei
• Liu Zenghe
• Goti Yohannes
• Feldman Benjamin J
• Hoss Udo

Classifications

• A61L31/048

  obtained by reactions only involving carbon-to-carbon unsaturated bonds (A61L31/041 takes precedence) · CPC title

• A61M2205/3592

  using telemetric means, e.g. radio or optical transmission · CPC title

• A61M2205/3569

  sublocal, e.g. between console and disposable · CPC title

• A61L31/047

  Other specific proteins or polypeptides not covered by A61L31/044 - A61L31/046 · CPC title

• A61L31/06

  obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds {(A61L31/041 takes precedence)} · CPC title