Foam-formed collagen strand

Patent metadata

Field	Value
Publication number	US-9771410-B2
Application number	US-201414334345-A
Country	US
Kind code	B2
Filing date	Jul 17, 2014
Priority date	Apr 23, 2010
Publication date	Sep 26, 2017
Grant date	Sep 26, 2017

Abstract

Foam-formed collagen strands and methods for forming strands involve depositing a dispersed solution of an isolated cleaned, de-fatted, enzymatically-treated (or non-enzyme treated) human-derived collagen product having a preserved amount of its natural constituents into grooves of a grooved plate, and processing the dispersed collagen product to provide a foam-formed collagen strand. Foam-formed collagen strands may be processed into threads having a matrix of reticulated pores to conduct biological materials in and through the strand, the collagen of the collagen strand comprising isolated, enzymatically-treated human derived collagen having a preserved amount of its natural collagen constituents.

First claim

What is claimed is:

1. A method for preparing a foam-formed human collagen strand, having a matrix of reticulated pores with a pore size from greater than 1 mm to less than 2 mm configured to allow movement of cells and fluid in and along the length of the strand, the method comprising: depositing a dispersed solution of an enzymatically-treated human-derived collagen product having a preserved amount of one or more native constituents into grooves of a grooved template to form a dispersed collagen product in said dispersed solution; and processing the dispersed collagen product to provide said foam-formed human collagen strand; wherein the matrix of reticulated pores comprises intersecting embossed surface channels to form a surface topography, and wherein the intersecting embossed surface channels include an axial channel extending between an embossed top surface channel intersection point and an embossed bottom surface channel intersection point.

2. The method of claim 1 , wherein the dispersed collagen product has a collagen density from about 0.1% to about 10%.

3. The method of claim 1 , wherein the dispersed collagen product comprises a sufficient amount of ethanol in the dispersion to prevent ice crystal formation and sharding.

4. The method of claim 1 , wherein said processing comprises removing the liquid component of the dispersed solution.

5. The method of claim 1 , wherein said processing comprises removing the liquid component by lyophilizing the dispersed solution.

6. The method of claim 1 , wherein said processing comprises cross-linking the collagen in said collagen dispersion.

7. The method of claim 1 , further comprising: removing the foam-formed human collagen strand from the grooved plate; and cross-linking the foam-formed collagen strand.

8. The method of claim 1 , further comprising: compressing the foam-formed collagen strand; and twisting the foam-formed collagen strand.

9. The method of claim 1 , further comprising coating the foam-formed human collagen strand with additional collagen, or a therapeutic agent that is released over time.

10. The method of claim 1 , further comprising adjusting the foam density or the porosity of the foam-formed collagen strand to match a resorption rate of the strand to a healing rate of a repair site.

11. The method of claim 1 , wherein said processing further comprises removing a liquid component by lyophilizing the dispersed solution, removing the foam-formed human collagen strand from the grooved plate, cross-linking the foam-formed collagen strand and adjusting the foam density or the porosity of the foam-formed collagen strand to match a resorption rate of the strand to a healing rate of a repair site.

Assignees

• Warsaw Orthopedic Inc

Inventors

• Lauritzen Nels
• Shimp Lawrence A
• Mitchell Brent S

Classifications

• A61L27/56

  Porous materials, {e.g. foams or sponges} · CPC title

• A61L17/08 Primary

  of animal origin, e.g. catgut, collagen · CPC title

• A61K9/0021

  Intradermal administration, e.g. through microneedle arrays or needleless injectors · CPC title

• A61L27/24

  Collagen · CPC title

• C08J2201/0484

  the liquid phase being aqueous · CPC title