Compositions and methods for wound healing

Patent metadata

Field	Value
Publication number	US-10322206-B2
Application number	US-201715472330-A
Country	US
Kind code	B2
Filing date	Mar 29, 2017
Priority date	Mar 29, 2016
Publication date	Jun 18, 2019
Grant date	Jun 18, 2019

Abstract

The present invention relates, in part, to sutures which promote wound closure and/or healing. In particular, the present invention provides fibrin microthread sutures that mimic the mechanical behavior of a target tissue thereby reducing, for example, scarring, inflammation, and cell death at the ligature site, including monofilament sutures.

First claim

What is claimed is:

1. A method for promoting wound closure and/or healing of a target tissue in a subject, comprising applying a monofilament suture to the target tissue, wherein the monofilament is:
a cohesive fibrin-based thread which mimics the stiffness behavior and elasticity of the target tissue and
is produced in a buffer solution.

2. The method of claim 1 , wherein the suture exhibits a stiffness of about 5 MPa to about 20 MPa as measured by Young's modulus.

3. The method of claim 1 , wherein the suture is associated with one or more of a substrate or a physiologically acceptable patch, a dressing, a bandage, or a natural or mechanical valve.

4. The method of claim 1 , wherein the target tissue is a soft tissue selected from skin, tendon, ligament, fascia, fibrous tissue, fat, synovial membrane, and muscle, nerve and blood vessel.

5. The method of claim 4 , wherein the soft tissue is skin.

6. The method of claim 1 , wherein the target tissue is hypertrophic or swollen.

7. The method of claim 1 , wherein the wound is a surgical wound.

8. The method of claim 7 , wherein the surgical wound results from aesthetic surgery.

9. The method of claim 7 , wherein the surgical wound results from skin grafting.

10. The method of claim 1 , wherein the wound is a trauma wound.

11. A method for promoting wound closure and/or healing of a target tissue, comprising applying a monofilament suture to the target tissue of a subject,
wherein the monofilament is a cohesive fibrin-based thread which mimics the stiffness behavior and elasticity of the target tissue and is produced in a buffer solution, and
wherein the subject has not received a standard of care suture.

12. The method of claim 11 , wherein the standard of care suture comprises silk, linen, nylon, polypropylene, polyamide, polyester, catgut, polyglycolic acid, polyglactin 910, poliglecaprone, or polydioxanone.

13. A method for promoting wound closure and/or healing of a target tissue, comprising applying a monofilament suture to the target tissue of a subject,
wherein the monofilament is a cohesive fibrin-based thread which mimics the stiffness behavior and elasticity of the target tissue and is produced in a buffer solution, and
wherein the subject has not received an adjuvant therapy.

14. The method of claim 13 , wherein the adjuvant therapy is selected from steroid, silicone, vitamin, laser treatment, radiotherapy, pressure dressing, collagen induction therapy, cryotherapy, or dermabrasion.

15. The method of claim 1 , wherein the monofilament suture is not a multifilament fibrin microthread.

Assignees

• Pins George
• Gaudette Glenn
• Collette Adam
• Edelman William
• Worcester Polytech Inst

Inventors

• Pins George
• Gaudette Glenn
• Collette Adam
• Edelman William

Classifications

• A61L17/10

  containing macromolecular materials · CPC title

• A61L17/12

  Homopolymers or copolymers of glycolic acid or lactic acid · CPC title

• A61P17/02

  for treating wounds, ulcers, burns, scars, keloids, or the like · CPC title

• A61L17/08 Primary

  of animal origin, e.g. catgut, collagen · CPC title