Allosteric hemoglobin modifiers with nitric oxide releasing moiety

Patent metadata

Field	Value
Publication number	US-9765017-B2
Application number	US-201415107962-A
Country	US
Kind code	B2
Filing date	Dec 22, 2014
Priority date	Dec 27, 2013
Publication date	Sep 19, 2017
Grant date	Sep 19, 2017

Abstract

Allosteric hemoglobin (Hb) modifiers of hemoglobin which contain nitric oxide (NO) moieties allowing for the release of NO in vivo. The compounds retain the oxygen delivery capability of the allosteric hemoglobin modifier to bind Hb and enhance Hb's ability to deliver oxygen to cells and tissues, and also release NO from the NO moiety. Methods of delivering oxygen and/or NO to cells and tissues are also provided.

First claim

We claim:

1. A compound having the general formula:

wherein
R1 and R2 are the same or different and are CH 3 , Cl, H, OCH 3 , or 5-carbon cyclic incorporating both R1 and R2;
R3 is H, OH, COOH, or OC 2 H 5 ;
R4 and R5 are the same or different and are H, CH 3 , cyclic incorporating both R4 and R5 and containing CH 3 substituents, OCH 3 , C 2 H 5 , phenyl, or unsubstituted phenyl; and
R6 is a NO containing moiety selected from the group consisting of:

2. The compound of claim 1 having the formula:

3. A composition, comprising:
one or more compounds as specified in claim 1 ; and
a carrier.

4. The composition of claim 3 wherein said carrier is a liquid, and wherein said one or more compounds are dissolved or distributed in said liquid.

5. The composition of claim 4 wherein said liquid is an aqueous liquid.

6. The composition of claim 4 wherein said liquid is an oil.

7. The composition of claim 3 , wherein said carrier is a solid.

8. The composition of claim 3 wherein said carrier is a gas.

9. The composition of claim 8 wherein said gas is air.

Assignees

• Univ Virginia Commonwealth

Inventors

• Safo Martin K
• Danso-Danquah Richmond
• Ghatge Mohini
• Venitz Jurgen
• Mangino Martin
• Ward Kevin R

Classifications

• A61P33/06

  Antimalarials · CPC title

• A61P37/00

  Drugs for immunological or allergic disorders · CPC title

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P9/00

  Drugs for disorders of the cardiovascular system · CPC title

• A61P35/00

  Antineoplastic agents · CPC title