Multi inlet for solvent assisted inlet ionisation

Patent metadata

Field	Value
Publication number	US-9761428-B2
Application number	US-201514821178-A
Country	US
Kind code	B2
Filing date	Aug 7, 2015
Priority date	Nov 2, 2011
Publication date	Sep 12, 2017
Grant date	Sep 12, 2017

Abstract

A mass spectrometer is disclosed comprising a dual channel Solvent Assisted Inlet Ionization (“SAII”) interface.

First claim

The invention claimed is:

1. A mass spectrometer comprising:
an atmospheric pressure ion source;
a first vacuum chamber;
a first ion inlet, wherein ions from said atmospheric pressure ion source are transmitted in use through said first ion inlet into said first vacuum chamber; and
a Solvent Assisted Inlet Ionisation (“SAII”) interface leading, separately from said first ion inlet, into said first vacuum chamber or a subsequent downstream vacuum chamber.

2. A mass spectrometer as claimed in claim 1 , further comprising a first capillary or fluid supply device for introducing a first substance into said mass spectrometer, wherein said first capillary or fluid supply device is received within said Solvent Assisted Inlet Ionisation interface.

3. A mass spectrometer as claimed in claim 2 , wherein said first substance comprises a lock mass substance.

4. A mass spectrometer as claimed in claim 2 , wherein said first substance comprises a reference substance, a calibration substance, a reagent or an analyte.

5. A mass spectrometer as claimed in claim 1 , further comprising one or more RF ion guides provided in a vacuum chamber downstream of said interface.

6. A mass spectrometer as claimed in claim 5 , wherein said one or more RF ion guides are arranged and adapted in a mode of operation to keep ions generated by said atmospheric pressure ion source separate from ions generated by or within said Solvent Assisted Inlet Ionisation interface.

7. A mass spectrometer as claimed in claim 5 , wherein said one or more RF ion guides comprise at least a first ion guiding path and a separate second ion guiding path.

8. A mass spectrometer as claimed in claim 7 , wherein ions formed in said atmospheric pressure ion source are directed to said first ion guiding path, and ions formed in a said Solvent Assisted Inlet Ionisation (“SAII”) interface are directed to said second ion guiding path.

9. A mass spectrometer as claimed in claim 7 , wherein said first and second ion guiding paths converge or join at a downstream section of said one or more RF ion guides.

10. A mass spectrometer as claimed in claim 7 , further comprising a device which may be switched from an ion transmission mode to an ion attenuation mode thereby preventing or substantially attenuating ions from passing along or exiting said first or said second ion guiding path.

11. A mass spectrometer as claimed in claim 7 , wherein ions directed into said ion guiding path are mass analysed by a first mass analyser, and ions directed into said second ion guiding path are mass analysed by a second mass analyser.

12. A mass spectrometer as claimed in claim 1 , wherein said atmospheric pressure ion source comprises an Electrospray Ionisation (“ESI”) ion source, an Atmospheric Pressure Chemical Ionisation (“APCI”) ion source, an Atmospheric Pressure Photo-Ionisation (“APPI”) ion source or an Impact spray ionisation ion source.

13. A mass spectrometer as claimed in claim 1 , wherein said Solvent Assisted Inlet Ionisation (“SAII”) interface comprises a single or dual channel Solvent Assisted Inlet Ionisation interface which communicates between an atmospheric pressure region and said first vacuum chamber.

14. A method of mass spectrometry comprising:
providing an atmospheric pressure ion source, a first vacuum chamber and a first ion inlet;
transmitting ions from said atmospheric pressure ion source through said first ion inlet into said first vacuum chamber; and
providing a Solvent Assisted Inlet Ionisation (“SAII”) interface leading, separately from said first ion inlet, into said first vacuum chamber or a subsequent downstream vacuum chamber.

15. A method as claimed in claim 14 , further comprising introducing a first substance into said mass spectrometer via said Solvent Assisted Inlet Ionisation (“SAII”) interface, wherein said first substance comprises a lock mass substance.

16. A mass spectrometer comprising:
a vacuum chamber;
a dual channel Solvent Assisted Inlet Ionisation (“SAII”) interface leading into said vacuum chamber;
an RF ion guide in said vacuum chamber, wherein in the RF ion guide comprises at least a first ion guiding path and a separate second ion guiding path.

17. A mass spectrometer as claimed in claim 16 , wherein ions entering said RF ion guide are directed either into said first ion guiding path or into said second ion guiding path.

18. A mass spectrometer as claimed in claim 16 , further comprising a device which may be switched from an ion transmission mode to an ion attenuation mode thereby preventing or substantially attenuating ions from passing along or exiting said first ion guiding path or said second ion guiding path.

19. A mass spectrometer as claimed in claim 16 , wherein said first ion guiding path and said second ion guiding path join or converge at a downstream section of said RF ion guide.

20. A mass spectrometer as claimed in claim 19 , wherein ions formed in a first of said dual channels are directed to said first ion guiding path, and ions formed in a second of said dual channels are directed to said second ion guiding path.

Assignees

• Micromass Ltd

Inventors

• Brown Jeffery Mark
• Green Martin Raymond
• Wildgoose Jason Lee

Classifications

• H01J49/0404

  Capillaries used for transferring samples or ions (electrospray nozzles H01J49/167) · CPC title

• H01J49/0468

  with means for heating or cooling the sample · CPC title

• H01J49/107 Primary

  Arrangements for using several ion sources · CPC title

• H01J49/16

  using surface ionisation, e.g. field-, thermionic- or photo-emission · CPC title

• H01J49/10

  Ion sources; Ion guns · CPC title