Hyaluronic acid derivatives
US-9301972-B2 · Apr 5, 2016 · US
US9745358B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9745358-B2 |
| Application number | US-201615212702-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jul 18, 2016 |
| Priority date | Mar 8, 2013 |
| Publication date | Aug 29, 2017 |
| Grant date | Aug 29, 2017 |
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The present invention provides new protease resistant polypeptides, as well as compositions and methods for treating, ameliorating or preventing conditions related to joint damage, including acute joint injury and arthritis.
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What is claimed is: 1. An isolated polypeptide comprising SEQ ID NO: 28. 2. A pharmaceutical composition comprising the isolated polypeptide of claim 1 . 3. The pharmaceutical composition of claim 2 further comprising a buffer. 4. The pharmaceutical composition of claim 2 further comprising sucrose. 5. The pharmaceutical composition of claim 2 , wherein the composition comprises sucrose and a buffer. 6. An isolated polypeptide consisting of SEQ ID NO: 28. 7. A pharmaceutical composition comprising the isolated polypeptide of claim 6 . 8. The pharmaceutical composition of claim 7 further comprising a buffer. 9. The pharmaceutical composition of claim 7 further comprising sucrose. 10. The pharmaceutical composition of claim 7 , wherein the composition comprises sucrose and a buffer.
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