Oligomer-tricyclic conjugates

Patent metadata

Field	Value
Publication number	US-9725431-B2
Application number	US-201314020196-A
Country	US
Kind code	B2
Filing date	Sep 6, 2013
Priority date	Nov 28, 2007
Publication date	Aug 8, 2017
Grant date	Aug 8, 2017

Abstract

The invention provides small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the small molecule drug not attached to the water-soluble oligomer.

First claim

What is claimed is:

1. A method of treatment, comprising administering a stable conjugate selected from:

wherein n is an integer from 1 to 30, to a patient in need thereof;
wherein the compound is administered for sedative, hypnotic, anti-anxiety, tranquilizing, anti convulsant, muscle relaxant, anti-depressant, or analgesic effect.

2. The method of claim 1 , wherein n is an integer from 1 to 10.

3. The method of claim 2 , wherein the stable conjugate has the structure:

4. The method of claim 3 , wherein n is 3, 5, 6, or 7.

5. The method of claim 2 , wherein the stable conjugate has the structure:

6. The method of claim 1 , wherein the stable conjugate is administered to treat pain.

7. The method of claim 6 , wherein the stable conjugate is administered to treat neuropathic pain.

8. The method of claim 6 , wherein the stable conjugate is administered to treat visceral pain.

9. A method of claim 1 , wherein the stable conjugate is administered as a pharmaceutical composition comprising the stable conjugate, and optionally, a pharmaceutically acceptable excipient.

10. The method of claim 9 , wherein the pharmaceutical composition is suitable for oral administration.

11. The method of claim 1 , wherein the stable conjugate is administered as a unit dosage form.

Assignees

• Nektar Therapeutics

Inventors

• Zhang Wen
• Gu Xuyuan
• Allums-Donald Stephanie
• Riggs-Sauthier Jennifer

Classifications

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P29/02

  without antiinflammatory effect · CPC title

• A61P29/00

  Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] · CPC title

• A61P25/24

  Antidepressants · CPC title

• A61P25/20

  Hypnotics; Sedatives · CPC title