High duty cycle ion spectrometer

Patent metadata

Field	Value
Publication number	US-9704696-B2
Application number	US-201615075082-A
Country	US
Kind code	B2
Filing date	Mar 18, 2016
Priority date	Nov 24, 2011
Publication date	Jul 11, 2017
Grant date	Jul 11, 2017

Abstract

An ion spectrometer is provided, comprising: an ion source, arranged to generate ions continuously with a first range of mass to charge ratios; and an ion trap, arranged to receive ions from the ion source along an axis, and to eject ions with a second range of mass to charge ratios orthogonally to that axis, the second range of mass to charge ratios being narrower than the first range of mass to charge ratios. In some embodiments, ions generated by the ion source continuously flow into the ion trap. Additionally or alternatively, ion optics receive ions ejected from the ion trap and cool the ions without substantial fragmentation. An ion analyser receives ions ejected from the ion trap or ion optics and separates the ions in accordance with at least one characteristic of the ions.

First claim

What is claimed is:

1. An ion spectrometer, comprising:
an ion source, arranged to generate ions continuously with a first range of mass to charge ratios;
a first ion trap, arranged to receive ions from the ion source along an axis, and to eject ions with a second range of mass to charge ratios orthogonally to that axis, the second range of mass to charge ratios being narrower than the first range of mass to charge ratios;
a power supply, coupled to the ion source and the first ion trap so as to provide a potential causing ions generated by the ion source to continuously flow into the first ion trap and to provide an excitation potential to the first ion trap to eject the ions with the second range of mass to charge ratios while at the same time other ions are received by the first ion trap and stored for future ejection;
a mass selector arranged to receive ions ejected from the first ion trap and configured to selectively transmit a subset of the ejected ions based on at least one property of the ions;
at least one of a second ion trap and a collision cell for receiving the ions selectively transmitted by the mass selector; and
an analyzer arranged to receive ions from the at least one of the second ion trap and the collision cell, for mass analyzing the received ions.

2. The ion spectrometer of claim 1 , wherein the mass selector comprises a mass filter.

3. The ion spectrometer of claim 1 , wherein the mass selector comprises an ion mobility separator.

4. The ion spectrometer of claim 1 , wherein the analyzer comprises a time-of-flight mass analyzer.

5. The ion spectrometer of claim 1 , wherein the analyzer comprises an orbital trapping mass analyzer.

6. A mass spectrometry method, comprising:
generating ions continuously in an ion source with a first range of mass to charge ratios;
receiving ions from the ion source at a first ion trap along an axis;
ejecting ions with a second range of mass to charge ratios from the first ion trap orthogonally to that axis, the second range of mass to charge ratios being narrower than the first range of mass to charge ratios;
concurrently with the ejecting step, receiving additional ions from the ion source at the first ion trap;
selecting a subset of the ejected ions for analysis based on at least one property;
directing the selected ions to at least one of a second ion trap and a collision cell; and
mass analyzing the selected ions, or ions derived therefrom, at a mass analyzer positioned to received ions from the second ion trap or collision cell.

7. The method of claim 6 , wherein the step of selecting a subset of the ejected ions comprises filtering ions in accordance with their mass to charge ratio.

8. The method of claim 6 , wherein the step of selecting a subset of the ejected ions comprises separating ions according to their ion mobility.

9. The method of claim 6 , wherein the step of directing the selected ions to at least one of an ion trap and a collision cell comprises fragmenting the ions in the collision cell to produce product ions.

10. The method of claim 6 , wherein the number of ions within the second range of mass to charge ratios is no more than 10% of the number of ions within the first range of mass to charge ratios.

11. The method of claim 6 , wherein the first ion trap comprises a quadrupole ion trap and wherein the step of ejecting ions with a second range of mass to charge ratios from the first ion trap comprises applying an excitation potential to a plurality of electrodes of the quadrupole ion trap, thereby causing ions with the second range of mass to charge ratios to be ejected from the first ion trap.

12. The method of claim 6 , wherein the step of mass analyzing is performed by a time-of-flight mass analyzer.

13. The method of claim 6 , wherein the step of mass analyzing is performed at an orbital trapping mass analyzer.

Assignees

• Thermo Fisher Scient (Bremen) Gmbh

Inventors

• Makarov Alexander Alekseevich

Classifications

• H01J49/427

  Ejection and selection methods · CPC title

• H01J49/401

  characterised by orthogonal acceleration, e.g. focusing or selecting the ions, pusher electrode · CPC title

• H01J49/0031

  Step by step routines describing the use of the apparatus (H01J49/0081 takes precedence) · CPC title

• H01J49/0481 Primary

  with means for collisional cooling · CPC title

• H01J49/426

  Methods for controlling ions · CPC title