High duty cycle ion spectrometer

Patent metadata

Field	Value
Publication number	US-9293315-B2
Application number	US-201514746753-A
Country	US
Kind code	B2
Filing date	Jun 22, 2015
Priority date	Nov 24, 2011
Publication date	Mar 22, 2016
Grant date	Mar 22, 2016

Abstract

An ion spectrometer is provided, comprising: an ion source, arranged to generate ions continuously with a first range of mass to charge ratios; and an ion trap, arranged to receive ions from the ion source along an axis, and to eject ions with a second range of mass to charge ratios orthogonally to that axis, the second range of mass to charge ratios being narrower than the first range of mass to charge ratios. In some embodiments, ions generated by the ion source continuously flow into the ion trap. Additionally or alternatively, ion optics receive ions ejected from the ion trap and cool the ions without substantial fragmentation. An ion analyzer receives ions ejected from the ion trap or ion optics and separates the ions in accordance with at least one characteristic of the ions.

First claim

What is claimed is:

1. An ion spectrometer, comprising:
an ion source arranged to generate ions continuously;
an ion selector device positioned to receive ions from the ion source and configured to select ions according to at least one characteristic thereof and to transmit the selected ions;
an ion trap, arranged to receive the selected ions from the ion separation device along an axis, and to eject ions orthogonally to that axis, the ion trap being configured to eject ions having a range of mass to charge ratios narrower than the range of mass to charge ratios of the selected ions received from the ion separation device;
a power supply, coupled to at least the ion trap so as to provide a potential causing ions selected by the ion selector device to continuously flow into the ion trap; and
an ion analyser, arranged to receive ions ejected from the ion trap and separate the ions in accordance with at least one characteristic of the ions.

2. The ion spectrometer of claim 1 , wherein the ion selector selects ions according to their mass-to-charge ratios.

3. The ion spectrometer of claim 2 , wherein the ion selector is a quadrupole mass analyser.

4. The ion spectrometer of claim 2 , wherein the ion selector is a time-of-flight mass analyser.

5. The ion spectrometer of claim 2 , wherein the ion selector is a magnetic sector mass analyser.

6. The ion spectrometer of claim 1 , wherein the ion selector selects ions according to their mobilities.

7. The ion spectrometer of claim 1 , further comprising:
ion optics, arranged to receive ions ejected from the ion trap and cool the ions; and
wherein the ion analyser is arranged to receive ions from the ion optics.

8. The ion spectrometer of claim 7 , wherein the ion trap and ion optics share a common housing.

9. The ion spectrometer of claim 7 , wherein the ion trap comprises an exit slit and the ion optics comprises an entrance slit and wherein the exit slit of the ion trap is located adjacent the entrance slit of the ion optics.

10. The ion spectrometer of claim 7 , wherein the ion optics is arranged to receive ions from the ion trap along a primary axis and to eject ions along a secondary axis, the secondary axis being orthogonal to the primary axis.

11. The ion spectrometer of claim 1 , wherein the ion trap is further arranged to store the received ions and to continue to store any received ions that are not ejected.

12. The ion spectrometer of claim 1 , wherein the ion trap comprises a plurality of electrodes, the power supply being arranged to supply a DC potential, an RF potential and an excitation potential to the plurality of electrodes, the power supply being further arranged such that the excitation potential causes ions to be ejected from the ion trap.

13. The ion spectrometer of claim 1 , wherein the ion analyser comprises a sequential scanning mass filter, arranged to receive ions ejected from the ion trap and to transmit ions sequentially according to their mass to charge ratio.

14. A mass spectrometry method, comprising:
generating ions continuously in an ion source;
selecting ions generated at the ion source according to at least one characteristic thereof;
passing the selected ions to an ion trap along an axis;
ejecting ions from the ion trap orthogonally to the axis, wherein the ejected ions have a range of mass-to-charge ratios narrower than a range of mass-to-charge ratios of the selected ions; and
receiving ions ejected from the ion trap at a mass analyser.

Assignees

• Thermo Fisher Scient Bremen

Inventors

• Makarov Alexander Alekseevich

Classifications

• H01J49/063

  Multipole ion guides, e.g. quadrupoles, hexapoles · CPC title

• H01J49/427

  Ejection and selection methods · CPC title

• H01J49/423

  with radial ejection · CPC title

• H01J49/0031

  Step by step routines describing the use of the apparatus (H01J49/0081 takes precedence) · CPC title

• H01J49/4295

  Storage methods · CPC title