Methods of treating an overweight or obese subject

Patent metadata

Field	Value
Publication number	US-9701651-B2
Application number	US-201514802473-A
Country	US
Kind code	B2
Filing date	Jul 17, 2015
Priority date	Dec 4, 2008
Publication date	Jul 11, 2017
Grant date	Jul 11, 2017

Abstract

The disclosure herein generally relates to methods of treating an overweight or obese condition, and overweight- or obesity-related conditions. In one embodiment, the disclosure provides a method of treating an overweight or obese condition involving administering to the subject in need thereof, an amount of a pharmaceutical composition including a MetAP-2 inhibitory compound, or a salt, ester, or prodrug thereof, effective to result in weight loss in the subject.

First claim

What is claimed is:

1. A compound represented by the formula C-D wherein C is represented by:

and D is represented by:

wherein:
Z, R and Y are not present;
X is C 1-6 alkyl;
P is NH 2 ; and

pharmaceutically acceptable salts thereof.

2. The compound of claim 1 , represented by:

wherein:
X is C 6 alkyl.

Assignees

• Zafgen Inc

Inventors

• Vath James E

Classifications

• C07D303/10

  in which the oxirane rings are condensed with a carbocyclic ring system having three or more relevant rings · CPC title

• A61P3/04

  Anorexiants; Antiobesity agents · CPC title

• C07D303/06

  in which the oxirane rings are condensed with a carbocyclic ring system having three or more relevant rings · CPC title

• C07D405/12

  linked by a chain containing hetero atoms as chain links · CPC title

• C07D303/22 Primary

  with monohydroxy compounds · CPC title