Hydrogels from dynamic covalent networks

Patent metadata

Field	Value
Publication number	US-9700635-B2
Application number	US-201514938577-A
Country	US
Kind code	B2
Filing date	Nov 11, 2015
Priority date	Nov 11, 2015
Publication date	Jul 11, 2017
Grant date	Jul 11, 2017

Abstract

A polymer is described herein that includes a plurality of N-J-N or N—C—S repeating units, wherein each J is independently a carbon atom, an alkyl group, or an aryl group; a plurality of hydrophilic groups bonded with the repeating units; and a plurality of hydrophobic groups bonded with the hydrophilic groups and the repeating units. Such polymers may be made into hydrogels by exposure to water, and the hydrogels may be used as delivery vehicles for various payloads.

First claim

What is claimed is:

1. A polymer, comprising:
a plurality of N-J-N repeating units, wherein each J is independently a carbon atom, an alkyl group, or an aryl group;
a plurality of hydrophilic groups bonded with the repeating units; and
a plurality of hydrophobic groups bonded with the hydrophilic groups and the repeating units, all in the general structure

wherein each instance of R 1 includes an acryloyl group, a lactone group, or a caprolactone group.

2. The polymer of claim 1 , wherein each instance of X is independently selected from the group consisting of a cholesterol, a polycarbonate, a polyoxazoline, a vitamin A, and a vitamin E.

3. A hydrogel formed by exposing the polymer of claim 1 to water.

4. A theranostic delivery matrix comprising the hydrogel of claim 3 .

Assignees

• IBM

Inventors

• Boday Dylan J
• Fevre Mareva B
• Garcia Jeannette M
• Hedrick James L
• Wojtecki Rudy J

Classifications

• C08G81/00 Primary

  Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers (involving only carbon-to-carbon unsaturated bond reactions C08F299/00 {; polyester-amides C08G69/44; polyester-imides C08G73/16; polyamides-imides C08G73/14; block- or graft polymers containing polysiloxane sequences C08G77/42}) · CPC title

• C08L79/04

  Polycondensates having nitrogen-containing heterocyclic rings in the main chain; Polyhydrazides; Polyamide acids or similar polyimide precursors · CPC title

• C09D179/06

  Polyhydrazides; Polytriazoles; Polyamino-triazoles; Polyoxadiazoles · CPC title

• A61K47/48215

  Human Necessities · mapped topic

• C08G73/0644 Primary

  Poly(1,3,5)triazines · CPC title