Oil-in-oil emulsified polymeric implants containing a hypotensive lipid and related methods

Patent metadata

Field	Value
Publication number	US-9669039-B2
Application number	US-201615144187-A
Country	US
Kind code	B2
Filing date	May 2, 2016
Priority date	Apr 30, 2004
Publication date	Jun 6, 2017
Grant date	Jun 6, 2017

Abstract

Biocompatible intraocular implants, such as microparticles, include a prostamide component and a biodegradable polymer that is effective in facilitating release of the prostamide component into an eye for an extended period of time. The prostamide component may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. Or, the prostamide component may be encapsulated by the polymeric component. The present implants include oil-in-oil emulsified implants or microparticles. Methods of producing the present implants are also described. The implants may be placed in an eye to treat or reduce at least one symptom of an ocular condition, such as glaucoma.

First claim

What is claimed is:

1. An intraocular implant comprising therapeutic polymeric microparticles, the microparticles made by the steps of: encapsulating a prostamide component with a polymeric component to form a population of prostamide-encapsulated microparticles by an oil-in-oil emulsion process.

2. The implant of claim 1 , wherein the oil-in-oil emulsion process comprises forming an oil-in-oil emulsion containing the prostamide component and the polymeric component; drying the emulsion to form a dried emulsion product; contacting the dried emulsion product with a solvent to form a solvent-containing composition; and removing the solvent from the solvent-containing composition to form the population of microparticles comprising the prostamide component and the polymeric component.

3. The implant of claim 1 , wherein the prostamide component of the microparticles so produced is encapsulated by the polymeric component to preserve therapeutic activity of the prostamide component after a terminal sterilization procedure.

4. The implant of claim 1 , wherein the polymeric component comprises a biodegradable polymer or biodegradable copolymer.

5. The implant of claim 1 , wherein the polymeric component comprises a poly(lactide-co-glycolide) PLGA copolymer.

6. The implant of claim 5 , wherein the PLGA copolymer has a lactide/glycolide ratio of 75/25 a molecular weight of about 63 kilodaltons, and an inherent viscosity of about 0.6 dL/g.

7. The implant of claim 2 , further comprising forming a first composition comprising the prostamide component, the polymeric component, and an organic solvent, and forming a second oil-containing composition, wherein the forming the oil-in-oil emulsion step comprises mixing the first composition and the second oil containing composition.

8. The implant of claim 2 , wherein the drying comprises evaporating the oil-in-oil emulsion to form an evaporated product.

9. The implant of claim 8 , further comprising suspending the evaporated product in the solvent before removing the solvent from the solvent-containing composition.

10. The implant of claim 1 , further comprising terminally sterilizing the polymeric microparticles.

Assignees

• Allergan Inc

Inventors

• Hughes Patrick M
• Boix Michele
• Sarrazin Christian
• Do Marina

Classifications

• A61P27/06

  Antiglaucoma agents or miotics · CPC title

• A61K31/165

  having aromatic rings, e.g. colchicine, atenolol, progabide · CPC title

• A61K31/216

  of acids having aromatic rings, e.g. benactizyne, clofibrate · CPC title

• A61K47/34

  Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers (A61K47/10 takes precedence) · CPC title

• B01J13/06

  by phase separation · CPC title