US9101583B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9101583-B2 |
| Application number | US-201414228020-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 27, 2014 |
| Priority date | Apr 30, 2004 |
| Publication date | Aug 11, 2015 |
| Grant date | Aug 11, 2015 |
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Biocompatible microparticles include an ophthalmically active cyclic lipid component and a biodegradable polymer that is effective, when placed into the subconjunctival space, in facilitating release of the cyclic lipid component into the anterior and posterior segments of an eye for an extended period of time. The cyclic lipid component can be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. Or, the cyclic lipid component can be encapsulated by the polymeric component. The present microparticles include oil-in-water emulsified microparticles. The subconjunctivally administered microparticles can be used to treat or to reduce at least one symptom of an ocular condition, such as glaucoma or age related macular degeneration.
Opening claim text (preview).
We claim: 1. A population of microparticles comprising a polymeric component encapsulating a prostamide component in the form of oil-in-water emulsified microparticles. 2. The population of claim 1 , wherein the polymeric component comprises a poly (lactide-co-glycolide) copolymer, and the prostamide component comprises at least one prostamide derivative selected from the group consisting of bimatoprost, salts thereof, and mixtures thereof.…
Human Necessities · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
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