Substituted 1,2,3,4,6,8,12,12a-octahydro-1,4-methanodipyrido[1,2-a:1',2'-d]pyrazines and methods for treating viral infections

Patent metadata

Field	Value
Publication number	US-9663528-B2
Application number	US-201514815504-A
Country	US
Kind code	B2
Filing date	Jul 31, 2015
Priority date	Dec 21, 2012
Publication date	May 30, 2017
Grant date	May 30, 2017

Abstract

Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I):

including stereoisomers and pharmaceutically acceptable salts thereof, wherein R 1 , X, W, Y 1 , Y 2 , Z 1 , and Z 4 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

First claim

What is claimed is:

1. A compound which is:

or a pharmaceutically acceptable salt thereof.

2. A pharmaceutical composition comprising a compound which is:

or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, diluent or excipient.

3. A compound which is:

or a pharmaceutically acceptable salt thereof.

4. A pharmaceutical composition comprising a compound which is:

or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, diluent or excipient.

Assignees

• Gilead Sciences Inc

Inventors

• Desai Manoj C
• Jin Haolun
• Lazerwith Scott E
• Pyun Hyung-Jung
• Taylor James G

Classifications

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P31/12

  Antivirals · CPC title

• A61P31/18

  for HIV · CPC title

• A61K31/529

  forming part of bridged ring systems · CPC title

• A61K31/551

  having two nitrogen atoms, e.g. dilazep · CPC title