Device with electrospray coating to deliver active ingredients

Patent metadata

Field	Value
Publication number	US-9642694-B2
Application number	US-201414579116-A
Country	US
Kind code	B2
Filing date	Dec 22, 2014
Priority date	Jan 31, 2006
Publication date	May 9, 2017
Grant date	May 9, 2017

Abstract

Devices to deliver one or more active ingredients for medical treatment may include a body of material presenting a surface including a polymer adapted to be rendered conductive such that one or more layers of electrospray particles are formable thereon or a body of conductive material presenting a surface upon which one or more layers of electrospray particles are formable thereon. A coating formed of electrospray particles may be deposited to adhere on the surface of the body of material (e.g., the coating may include one or more layers of coating material, at least one layer of the one or more layers of coating material may include an open matrix coating, the open matrix coating may include one or more active ingredients, the open matrix coating may include one or more polymers and one or more active ingredients, etc.).

First claim

What is claimed is:

1. A device to deliver one or more active ingredients, wherein the device comprises:
a body of material presenting a surface comprising a polymer adapted to be rendered conductive such that one or more layers of electrospray particles are formable thereon; and
a coating formed of electrospray particles deposited to adhere on the surface of the body of material, wherein the coating comprises one or more layers of coating material, wherein at least one layer of the one or more layers of coating material comprises an open matrix coating having an upper surface wherein a supermajority of the electrospray particles are visibly discrete but attached creating an irregular coating, wherein the open matrix coating comprises open regions extending at least one or more nominal particle diameters deeper in the upper surface, wherein the nominal diameter of the electrospray particles is in a range of about lnm to about 2000 nm, and further wherein the upper surface of the open matrix coating comprises a rough surface wherein the surface area thereof is greater than about 1.2 times a surface area of a completely smooth surface having a substantially identical shape, and further wherein the open matrix coating comprises one or more active ingredients.

2. The device of claim 1 , wherein the surface comprising the polymer comprises a dissolvable polymer.

3. The device of claim 2 , wherein the dissolvable polymer comprises a water soluble polymer.

4. The device of claim 3 , wherein the water soluble polymer comprises at least one of a polysaccharide, a protein, and a glycan.

5. The device of claim 4 , wherein the water soluble polymer comprises at least a polysaccharide.

6. The device of claim 5 , wherein the water soluble polymer comprises at least a cellulosic polymer.

7. The device of claim 3 , wherein the water soluble polymer comprises at least one of an acrylate, polyethylene oxide, polyvinyl alcohol, polyacrylic acid, polyethylene glycol, and polyvinylpyrrolidone.

8. The device of claim 2 , wherein the thickness of the dissolvable polymer is at least about 1 micron and not greater than 30 microns.

9. The device of claim 1 , wherein the open matrix coating comprises one or more polymers and one or more active ingredients.

10. The device of claim 9 , wherein the one or more active ingredients comprises at least a biologically active ingredient.

11. The device of claim 9 , wherein the one or more active ingredients comprises a drug which remains in an amorphous state distributed throughout the one or more polymers.

12. The device of claim 9 , wherein the one or more active ingredients comprise at least one pharmaceutically active compound.

13. The device of claim 9 , wherein the one or more polymers of the open matrix coating comprises at least one of a cellulosic polymer, an acrylate, polyethylene oxide, polyvinyl alcohol, polyacrylic acid, polyethylene glycol, and polyvinylpyrrolidone.

14. The device of claim 13 , wherein the one or more polymers of the open matrix coating comprises at least a cellulosic polymer.

15. The device of claim 1 , wherein at least one layer of the one or more layers of coating material comprises an open matrix coating and at least one layer of the one or more layers of coating material comprises a closed film coating.

16. The device of claim 15 , wherein the open matrix coating comprises a surface area greater than about 1.5 times the surface area of a completely smooth surface.

17. The device of claim 16 , wherein the closed film coating comprises a surface area that is about equal to the surface area of a completely smooth surface.

18. The device of claim 1 , wherein the device is configured to be used, at least in part, to penetrate and/or be positioned within a body.

19. The device of claim 18 , wherein the device is configured as, at least in part, a medical closure.

20. The device of claim 18 , wherein the device is configured as, at least in part, an implantable device.

21. The device of claim 1 , wherein the open matrix coating comprises a surface area greater than about 1.5 times the surface area of a completely smooth surface.

22. A device to deliver one or more active ingredients, wherein the device comprises:
a body of conductive material presenting a surface upon which one or more layers of electrospray particles are formable thereon; and
a coating formed of electrospray particles deposited to adhere on the surface of the body of material, wherein the coating comprises one or more layers of coating material, wherein at least one layer of the one or more layers of coating material comprises an open matrix coating having an upper surface wherein a supermajority of the electrospray particles are visibly discrete but attached creating an irregular coating, wherein the open matrix coating comprises open regions extending at least one or more nominal particle diameters deeper in the upper surface, wherein the nominal diameter of the electrospray particles is in a range of about 1 nm to about 2000 nm, and further wherein the upper surface of the open matrix coating comprises a rough surface wherein the surface area thereof is greater than about 1.2 times a surface area of a completely smooth surface having a substantially identical shape, and further wherein the open matrix coating comprises one or more polymers and one or more active ingredients.

23. The device of claim 22 , wherein the one or more active ingredients comprises at least a biologically active ingredient.

24. The device of claim 22 , wherein the one or more active ingredients comprises a drug which remains in an amorphous state distributed throughout the one or more polymers.

25. The device of claim 22 , wherein the one or more active ingredients comprise at least one pharmaceutically active compound.

26. The device of claim 22 , wherein the one or more polymers of the open matrix coating comprises at least one of a cellulosic polymer, an acrylate, polyethylene oxide, polyvinyl alcohol, polyacrylic acid, polyethylene glycol, and polyvinylpyrrolidone.

27. The device of claim 26 , wherein the one or more polymers of the open matrix coating comprises at least a cellulosic polymer.

28. The device of claim 22 , wherein at least one layer of the one or more layers of coating material comprises an open matrix coating and at least one layer of the one or more layers of coating material comprises a closed film coating.

29. The device of claim 22 , wherein the device is configured to be used, at least in part, to penetrate and/or be positioned within a body.

30. The device of claim 22 , wherein the open matrix coating comprises a surface area greater than about 1.5 times the surface area of a completely smooth surface.

Assignees

• Nanocopoeia Inc
• Univ Minnesota

Inventors

• Hoerr Robert A
• Chen Da-Ren
• Carlson John V
• Pui David Y H

Classifications

• B05B5/08

  Plant for applying liquids or other fluent materials to objects · CPC title

• B05D1/04

  involving the use of an electrostatic field {(B05D1/025 and B05D1/14 take precedence)} · CPC title

• C25D17/007

  Current directing devices · CPC title

• B05D1/06

  Applying particulate materials · CPC title

• C25D5/003

  Electroplating using gases, e.g. pressure influence · CPC title