Atherosclerosis-targeted liposome nanocarrier delivery system and preparation method therefor
US-2024424132-A1 · Dec 26, 2024 · US
US9623006B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9623006-B2 |
| Application number | US-201514692042-A |
| Country | US |
| Kind code | B2 |
| Filing date | Apr 21, 2015 |
| Priority date | Jun 9, 2008 |
| Publication date | Apr 18, 2017 |
| Grant date | Apr 18, 2017 |
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Described herein are compounds for and methods of treating conditions or diseases in a subject by administering to the subject a pharmaceutical composition containing an effective amount of an α-adrenergic modulator. The compounds and methods are also useful for alleviating types of pain, acute, neuropathic and chronic.
Opening claim text (preview).
What is claimed is: 1. A method of treating a disease or condition in a mammal, the method comprising administering to the mammal in need thereof a pharmaceutically effective dose of N-(2,3-dichlorobenzyl)-4,5-dihydro-1H-imidazol-2-amine having the following structure: or a pharmaceutically acceptable salt thereof; wherein the disease or condition is selected from the group consisting of optic neuropathy, corneal pain and diabetic retinopathy. 2. The method according to claim 1 , wherein the disease or condition is corneal pain. 3. The method according to claim 1 , wherein the disease or condition is optic neuropathy. 4. The method according to claim 1 , wherein the disease or condition is diabetic retinopathy. 5. The method according to claim 1 , wherein the mammal is a human.
Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] · CPC title
Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole · CPC title
having a nitrogen attached in position 2, e.g. clonidine · CPC title
with carbocyclic radicals directly attached to said nitrogen atoms · CPC title
having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil · CPC title
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