Substituted quinazolines, the preparation thereof and the use thereof in pharmaceutical compositions
US-8962636-B2 · Feb 24, 2015 · US
US9155705B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9155705-B2 |
| Application number | US-93563409-A |
| Country | US |
| Kind code | B2 |
| Filing date | Apr 2, 2009 |
| Priority date | Apr 3, 2008 |
| Publication date | Oct 13, 2015 |
| Grant date | Oct 13, 2015 |
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The present invention relates to pharmaceutical compositions comprising fixed dose combinations of a DPP-4 inhibitor drug and a partner drug, processes for the preparation thereof, and their use to treat certain diseases.
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The invention claimed is: 1. A solid pharmaceutical composition comprising or made from: (a) 1-[(4-methyl-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-(3-(R)-amino-piperidin-1-yl)-xanthine in a dosage range from about 0.5 mg to about 10 mg, (b) metformin hydrochloride, (c) a pharmaceutical excipient, and (d) about 1 mg to 50 mg of L-arginine. 2. The pharmaceutical composition according to claim 1 , wherein the 1-[(4-methyl-quinazolin-2-yl)methy…
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