Devices, methods, and systems of functional optical coherence tomography

Patent metadata

Field	Value
Publication number	US-9619903-B2
Application number	US-201514698641-A
Country	US
Kind code	B2
Filing date	Apr 28, 2015
Priority date	Apr 28, 2014
Publication date	Apr 11, 2017
Grant date	Apr 11, 2017

Abstract

The present disclosure provides systems and methods for the determining a rate of change of one or more analyte concentrations in a target using non invasive non contact imaging techniques such as OCT. Generally, OCT data is acquired and optical information is extracted from OCT scans to quantitatively determine both a flow rate of fluid in the target and a concentration of one or more analytes. Both calculations can provide a means to determine a change in rate of an analyte over time. Example methods and systems of the disclosure may be used in assessing metabolism of a tissue, where oxygen is the analyte detected, or other functional states, and be generally used for the diagnosis, monitoring and treatment of disease.

First claim

What is claimed is:

1. A method for imaging a target, the method comprising:
a. performing optical coherence tomography (OCT) scanning on a target with one or more beams of low coherence light, wherein the one or more beams of low coherence light comprise one or more wavelengths and the one or more beams of light are used to perform a single measurement;
b. acquiring optical information from reflected signals generated by the performed OCT scanning in the single measurement;
c. quantitatively three dimensional (3D) imaging the target in the single measurement;
d. concurrently determining a flow rate of a fluid and a concentration of one or more analytes, from the acquired optical information and the 3D imaging in the single measurement; and
e. determining a rate of change of the one or more analyte concentrations in the target based on the determining of flow rate of a fluid and a concentration of one or more analytes.

2. The method of claim 1 , wherein the quantitatively 3D-imaging in the target is performed without contacting at least one analyte with an exogenous reagent or label.

3. The method of claim 1 , wherein the one or more beams of light comprises invisible light or visible light.

4. The method of claim 1 , wherein the OCT scanning generates one or more A-scans.

5. The method of claim 4 , wherein the quantitatively imaging a flow rate of a fluid in the target and a concentration of one or more analytes in the fluid in the target, and the determining rate of change of one more analyte concentrations use spectral analysis of the same A-scan.

6. The method of claim 4 , wherein the amplitude, intensity or phase, of the same OCT A-scan, are used for determining a rate of change of the one or more analyte concentrations.

7. The method of claim 4 , wherein the flow rate, the concentration of one or more analytes, and the determining the rate of change or one or more analyte concentrations uses a plurality of OCT A-scans of the target.

8. The method of claim 4 , wherein OCT is performed on a plurality of areas in the target.

9. The method of claim 1 , wherein the one or more beams of light are used to perform multi-beam or multi-band scanning OCT.

10. The method of claim 1 , wherein the one or more beams of light illuminate the target concurrently or sequentially.

11. The method of claim 1 , wherein the quantitatively imaging a flow rate of a fluid in the target and a concentration of one or more analytes in the fluid in the target occur substantially simultaneously.

12. The method of claim 1 , wherein the OCT scanning on the target is performed with identical or different pre-defined scanning trajectories.

13. The method of claim 1 , wherein the target is selected from the group consisting of tissue, healthy tissue, diseased tissue, retina, tumor, cancer, growth, fibroid, lesion, skin, mucosal lining, organ, graft, blood supply and one or more blood vessels.

14. The method of claim 1 , wherein the quantitatively imaging a flow rate of a fluid in the target is performed using either visible light or invisible light.

15. The method of claim 1 , wherein the quantitatively imaging a concentration of one or more analytes in the fluid in the target is performed using either visible light or invisible light.

16. The method of claim 1 , wherein the fluid is selected from the group consisting of whole blood, blood plasma, blood serum, urine, semen, tears, sweat, saliva, lymph fluid, pleural effusion, peritoneal fluid, meningal fluid, amniotic fluid, glandular fluid, spinal fluid, conjunctival fluid, vitreous, aqueous, vaginal fluid, bile, mucus, sputum and cerebrospinal fluid.

17. The method of claim 1 , wherein the analyte is selected from the group consisting of oxygen, hemoglobin, oxygenated hemoglobin, deoxygenated hemoglobin, glucose, sugar, blood area nitrogen, lactate, hematocrit, biomarker and nucleic acid.

18. The method of claim 1 , wherein determining the rate of change of one or more analytes is performed by comparing or using a reference.

19. The method of claim 18 , wherein the reference is healthy tissue.

20. The method of claim 18 , wherein the reference is the target in which the flow rate of a fluid and the concentration of one or more analytes have been previously been quantified.

21. The method of claim 1 , wherein one or more images of the target are generated.

22. The method of claim of claim 21 , wherein the one or more images and the change in rate of analyte concentration are used to calculate a function of the target or a change in the function of the target.

23. The method of claim 22 , wherein the function of the target is a pathological alteration in a tissue.

24. The method of claim 22 , wherein the function of the target is a metabolic function.

25. The method of claim 21 , wherein arteries and veins are identified in the one or more images.

26. The method of claim 25 , wherein the metabolic function is calculated in one or more areas of the target.

27. The method of claim 1 , wherein an exogenous agent is contacted with the target.

28. The method of claim 1 , wherein the exogenous agent is a contrast reagent.

29. The method of claim 1 , wherein the quantifying a flow rate of a fluid in the target comprises determining the cross sectional area of one or more vessels containing the fluid.

30. The method of claim 1 , wherein a medical decision is made by determining the rate of change of the one or more analyte concentrations in the target.

31. The method of claim 1 , wherein spectral analysis is performed to extract a full set of optical properties of the target.

32. The method of claim 1 , wherein the method is configured for a device selected from the group consisting of probe, handheld device, wearable device, endoscope, catheter probe, laparoscopic tool, surgical tool, and needle.

33. The method of claim 1 , wherein the method is configured to screen or optimize one or more drugs, treatment protocols or pharmaceutical reagents.

Assignees

• Univ Northwestern

Inventors

• Yi Ji
• Liu Wenzhong
• Backman Vadim
• Zhang Hao F

Classifications

• G06T12/00

  Tomographic reconstruction from projections · CPC title

• A61B1/046

  for infrared imaging · CPC title

• G06T2207/10101

  Optical tomography; Optical coherence tomography [OCT] · CPC title

• G06T7/0012

  Biomedical image inspection · CPC title

• G06F17/10

  Complex mathematical operations {(function generation by table look-up G06F1/03; evaluation of elementary functions by calculation G06F7/544)} · CPC title