Nutritional compositions containing synergistic combination and uses thereof

Patent metadata

Field	Value
Publication number	US-9609888-B2
Application number	US-201313955492-A
Country	US
Kind code	B2
Filing date	Jul 31, 2013
Priority date	Jul 31, 2013
Publication date	Apr 4, 2017
Grant date	Apr 4, 2017

Abstract

A composition and method for enhancing brain development in a pediatric subject, the method including administering to the pediatric subject a nutritional composition having up to about 7 g/100 kcal of a fat or lipid source, wherein the fat or lipid source includes at least about 0.5 mg/100 kcal of milk or non-milk polar lipids; up to about 5 g/100 kcal of a protein source; at least about 15 mg/100 kcal of lactoferrin from a non-human source; about 0.015 g/100 kcal to about 0.15 g/100 kcal of a prebiotic composition including polydextrose and/or galactooligosaccharide; and at least about 5 mg/100 kcal of a source of long chain polyunsaturated fatty acids.

First claim

What is claimed is:

1. A method for enhancing brain development in a pediatric subject, the method comprising administering to the pediatric subject a nutritional composition comprising:
a. up to about 7 g/100 kcal of a fat or lipid source, wherein the fat or lipid source comprises at least about 0.5 mg/100 kcal polar lipids, wherein the polar lipids comprise gangliosides and phospholipids, and further wherein the gangliosides are present at a level of about 0.5 mg/100 kcal to about 18 mg/100 kcal, and the phospholipids are present at a level of about 20 mg/100 kcal to about 250 mg/100 kcal;
b. up to about 5 g/100 kcal of a protein source;
c. at least about 15 mg/100 kcal of lactoferrin from a non-human source;
d. a prebiotic composition, wherein at least 20% of the prebiotic composition comprises polydextrose, galactooligosaccharide or a combination thereof;
e. at least about 5 mg/100 kcal of a source of long chain polyunsaturated fatty acids comprising docosahexaenoic acid; and
f. a preservative.

2. The method of claim 1 , wherein the polar lipids are present at a level of about 0.5 mg/100 kcal to about 470 mg/100 kcal.

3. The method of claim 2 , wherein the polar lipids are present at a level of about 10 mg/100 kcal to about 350 mg/100 kcal.

4. The method of claim 3 , wherein the polar lipids are present at a level of about 20 mg/100 kcal to about 260 mg/100 kcal.

5. The method of claim 1 , wherein lactoferrin is present at a level of about 10 mg/100 kcal to about 200 mg/100 kcal.

6. The method of claim 5 , wherein the lactoferrin is bovine lactoferrin.

7. The method of claim 1 , wherein the source of long chain polyunsaturated fatty acids is present more preferably from about 5 mg/100 kcal to about 75 mg/100 kcal.

8. The method of claim 1 , wherein the nutritional composition is an infant formula or a growing up milk.

9. A nutritional composition for enhancing brain development in a pediatric subject, comprising:
a. up to about 7 g/100 kcal of a fat or lipid source, wherein the fat or lipid source comprises at least about 0.5 mg/100 kcal polar lipids, wherein the polar lipids comprise gangliosides and phospholipids, and further wherein the gangliosides are present at a level of about 0.5 mg/100 kcal to about 18 mg/100 kcal, and the phospholipids are present at a level of about 20 mg/100 kcal to about 250 mg/100 kcal;
b. up to about 5 g/100 kcal of a protein source;
c. at least about 15 mg/100 kcal of lactoferrin from a non-human source;
d. a prebiotic composition, wherein at least 20% of the prebiotic composition comprises polydextrose, galactooligosaccharide or a combination thereof;
e. at least about 5 mg/100 kcal of a source of long chain polyunsaturated fatty acids comprising docosahexaenoic acid; and
f. a preservative.

10. The composition of claim 9 , wherein the polar lipids are present at a level of about 0.5 mg/100 kcal to about 470 mg/100 kcal.

11. The composition of claim 10 , wherein the polar lipids are present at a level of about 10 mg/100 kcal to about 350 mg/100 kcal.

12. The composition of claim 11 , wherein the polar lipids are present at a level of about 20 mg/100 kcal to about 260 mg/100 kcal.

13. The composition of claim 9 , wherein lactoferrin is present at a level of about 15 mg/100 kcal to about 300 mg/100 kcal.

14. The composition of claim 13 , wherein the lactoferrin is bovine lactoferrin.

15. The composition of claim 9 , wherein the source of long chain polyunsaturated fatty acids is present more preferably from about 5 mg/100 kcal to about 75 mg/100 kcal.

16. The composition of claim 9 , wherein the nutritional composition is an infant formula or a growing up milk.

17. The method of claim 1 , wherein the prebiotic composition is present in the nutritional composition from about 1.0 g/L to about 10.0 g/L.

18. The composition of claim 9 , wherein the prebiotic composition is present from about 1.0 g/L to about 10.0 g/L.

19. The method of claim 1 , wherein the pediatric subject is an infant and further wherein the gangliosides are present at a level of about 0.5 mg/100 kcal to about 12 mg/100 kcal and the phospholipids are present at a level of about 20 mg/100 kcal to about 50 mg/100 kcal.

20. The method of claim 1 , wherein the pediatric subject is an infant between birth and 6 months of age, and further wherein the gangliosides are present at a level of about 0.5 mg/100 kcal to about 9 mg/100 kcal and the phospholipids are present at a level of about 20 mg/100 kcal to about 150 mg/100 kcal.

Assignees

• Mead Johnson Nutrition Co

Inventors

• Berg Brian
• Jouni Zeina
• Wittke Anja
• Waworuntu Rosaline
• Chichlowski Maciej

Classifications

• A61K38/018

  from milk · CPC title

• A61K31/685

  one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin · CPC title

• A23L33/26 Primary

  Polyol polyesters, e.g. sucrose polyesters; Synthetic sugar polymers, e.g. polydextrose · CPC title

• A61K31/202

  having three or more double bonds, e.g. linolenic (eicosanoids, e.g. leukotrienes A61K31/557) · CPC title

• A61K31/702

  Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages · CPC title