Decreasing bacterial responses on nano-modified titanium

Patent metadata

Field	Value
Publication number	US-9605349-B2
Application number	US-201414570374-A
Country	US
Kind code	B2
Filing date	Dec 15, 2014
Priority date	Dec 15, 2014
Publication date	Mar 28, 2017
Grant date	Mar 28, 2017

Abstract

Methods of manufacturing produce metal implants having nano-modified surfaces that contain antimicrobial properties. The methods may include immersing the implant in an acid, rinsing the acid-treated implant in an aqueous cleaner, and thereafter heating the rinsed implant. The nano-modified implants described herein may contain an increased surface roughness; surface features with increased width or height; and/or decreased surface energy. The implants that result from these methods contain a nano-modified surface that is resistant to microbial cell adhesion and ultimately reduce biomaterials-related infections at the implant site.

First claim

The invention claimed is:

1. A method of manufacturing an implant, comprising:
a) immersing the implant in acid at a concentration of 5N to 15N for 30 minutes to 120 minutes;
b) rinsing the acid-treated implant in an aqueous cleaner having a pH of 6 to 8 to remove the acid; and
c) heating the rinsed implant at a temperature between 400° C. and 600° C. for about 30 minutes to about 60 minutes.

2. The method of claim 1 , wherein the implant is a metal selected from the group consisting of commercially pure titanium, and titanium alloy.

3. The method of claim 1 , wherein at least a portion of implant is porous prior to immersing in the acid.

4. The method of claim 1 , wherein the implant is non-porous prior to immersing in the acid.

5. The method of claim 1 , wherein the acid is selected from the group consisting of nitric acid, phosphoric acid, and sulfuric acid.

6. The method of claim 1 , wherein the acid is nitric acid.

7. The method of claim 1 , wherein the concentration of the acid is 1N to 10N.

8. The method of claim 1 , wherein the implant is immersed in the acid for 30 minutes to 60 minutes.

9. The method of claim 1 , wherein the implant is rinsed with deionized water.

10. The method of claim 1 , wherein the implant is rinsed for 2 minutes to 10 minutes.

11. The method of claim 1 , further comprising drying the rinsed implant overnight at room temperature before heating the rinsed implant to between 400° C. and 600° C.

12. The method of claim 1 , wherein the temperature of the implant during heating is increased from ambient temperature to a predetermined temperature at a rate of 10° Celsius per minute.

Assignees

• Howmedica Osteonics Corp

Inventors

• Webster Thomas J
• Dimaano Godofredo R
• Tenhuisen Kevor Shane
• Kulesha Gene
• Muth John

Classifications

• A61F2002/3084

  Nanostructures · CPC title

• A61L31/022 Primary

  Metals or alloys · CPC title

• C23F1/26 Primary

  for etching refractory metals · CPC title

• A61L2400/12

  Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces · CPC title

• A61L27/06

  Titanium or titanium alloys · CPC title