Scaffold for tissue regeneration in mammals

Patent metadata

Field	Value
Publication number	US-9561250-B2
Application number	US-201313936702-A
Country	US
Kind code	B2
Filing date	Jul 8, 2013
Priority date	Jul 16, 2009
Publication date	Feb 7, 2017
Grant date	Feb 7, 2017

Abstract

A three-dimensional scaffold with interconnected pores for repair of tissue comprising a scaffold body for structural support of the tissue scaffold, where the scaffold body comprises scaffold body components bonded to each other and made from component materials comprising about 40 to about 90 wt % B 2 O 3 , and two or more other oxides, wherein the scaffold body has a porosity between about 15 and about 90 vol %.

First claim

The invention claimed is:

1. A three-dimensional scaffold with interconnected pores for repair of tissue comprising:
a scaffold body for structural support of the tissue scaffold comprising:
scaffold body components bonded to each other to define the scaffold body and provide a scaffold body compressive strength of greater than 5 MPa, wherein the scaffold body components are components in the form of fibers in combination with one or more components in the form of ribbons, solid spheres, hollow spheres, and particles, and the components are of a component material comprising, by approximate weight %:

B 2 O 3
40 to 90 

Na 2 O
0 to 25

Li 2 O
0 to 25

K 2 O
0 to 25

Rb 2 O
0 to 25

CaO
0 to 40

MgO
0 to 25

SrO
0 to 40

BaO
0 to 50

P 2 O 5
0 to 10

SiO 2
0 to 18

Al 2 O 3
0 to 3 

F
0 to 4 

transition metal elements
0 to 10

cumulative

wherein two or more of Li 2 O, Na 2 O, K 2 O, and Rb 2 O are present in a cumulative concentration between about 1 and about 50 wt %,
wherein two or more of MgO, SrO, BaO, and CaO are present in a cumulative concentration between about 1 and about 50 wt %,
wherein the scaffold body has a porosity between about 15 and about 90 vol %.

2. The scaffold of claim 1 wherein the B 2 O 3 concentration is between about 50 and about 90 wt %.

3. The scaffold of claim 1 wherein the B 2 O 3 concentration is between about 60 and about 82 wt %.

4. The scaffold of claim 1 wherein:
the B 2 O 3 concentration is between 50 and 90 wt %;
the component material comprises two or more oxides from among Li2O, Na 2 O, K 2 O, and Rb 2 O in a cumulative concentration between 5 and 25 wt % and two or more oxides from among MgO, SrO, BaO, and CaO in a cumulative concentration between 1 and 45 wt %; and
less than 5 wt % of the component material is crystalline material.

5. The scaffold of claim 1 wherein the scaffold body components contain MgO in a concentration is between about 1 and 25 wt %.

6. The scaffold of claim 1 wherein the scaffold body components contain K 2 O in a concentration is between about 1 and 25 wt % and MgO in a concentration is between about 1 and 25 wt %.

7. The scaffold of claim 1 wherein the component material comprises two or more oxides from among Li 2 O, Na 2 O, K 2 O, and Rb 2 O in a cumulative concentration between 5 and 25 wt %.

8. The scaffold of claim 1 wherein the component material comprises two or more oxides from among Li 2 O, Na 2 O, K 2 O, and Rb 2 O in a cumulative concentration between 5 and 25 wt % and two or more oxides from among MgO, SrO, BaO, and CaO in a cumulative concentration between 1 and 45 wt %.

9. The scaffold of claim 1 wherein the component material further comprises one or more elements selected from the group consisting of Zn, Cu, Fe, Mn, Si, Sr, Ni, Mo, and Se, in an amount between about 0.01 and 10 wt % per element and cumulatively less than 25 wt %.

10. The scaffold of claim 1 wherein the component material further comprises between about 0.01 and 10 wt % Cu as copper oxide.

11. A three-dimensional scaffold with interconnected pores for repair of tissue comprising:
a scaffold body for structural support of the tissue scaffold comprising:
scaffold body components bonded to each other to define the scaffold body and provide a scaffold body compressive strength of greater than 0.4 MPa, wherein the scaffold body components are of a component material comprising, by approximate weight %:

B 2 O 3
40 to 90 

Na 2 O
0 to 25

Li 2 O
0 to 25

K 2 O
0 to 25

Rb 2 O
0 to 25

CaO
0 to 40

MgO
0 to 25

SrO
0 to 40

BaO
0 to 50

P 2 O 5
0 to 10

SiO 2
0 to 18

Al 2 O 3
0 to 3 

F
0 to 4 

transition metal elements
0 to 10

cumulative

wherein two or more of Li 2 O, Na 2 O, K 2 O, and Rb 2 O are present in a cumulative concentration between about 1 and about 50 wt %, 0
wherein two or more of MgO, SrO, BaO, and CaO are present in a cumulative concentration between about 1 and about 50 wt %,
wherein the scaffold body has a porosity between about 15 and about 90 vol %, and
wherein at least 10 wt % of the scaffold body components have a first composition and at least 10 wt % of the scaffold body components have a second compositi

Assignees

• Univ Missouri

Inventors

• Day Delbert E
• Jung Steven B
• Brown Roger F

Classifications

• C03C3/14

  containing boron · CPC title

• C03C13/00

  Fibre or filament compositions (manufacture of fibres or filaments C03B37/00) · CPC title

• A61L27/56

  Porous materials, {e.g. foams or sponges} · CPC title

• C03C3/19

  containing boron · CPC title

• A61K33/22 Primary

  Boron compounds · CPC title