Reduced coenzyme Q10 crystal having excellent stability

Patent metadata

Field	Value
Publication number	US-9556098-B2
Application number	US-201615181511-A
Country	US
Kind code	B2
Filing date	Jun 14, 2016
Priority date	Jun 24, 2011
Publication date	Jan 31, 2017
Grant date	Jan 31, 2017

Abstract

With respect to reduced coenzyme Q10, there has been no report about the presence of crystal polymorphism, and it has been considered that a conventionally obtained crystal form is only one form. The present invention relates to a reduced coenzyme Q10 crystal having an endothermic peak indicating melting at 54±2° C. during temperature rise at a rate of 5° C./min by differential scanning calorimetry (DSC), and/or to a reduced coenzyme Q10 crystal showing characteristic peaks at diffraction angles (2θ±0.2°) of 11.5°, 18.2°, 19.3°, 22.3°, 23.0° and 33.3° by powder X-ray (Cu—Kα) diffraction. The crystal form is a novel reduced coenzyme Q10 crystal which has a higher melting point and a lower solubility in a solvent, and is more excellent in stability than the conventionally known reduced coenzyme Q10 crystal.

First claim

The invention claimed is:

1. A composition, comprising:
a reduced coenzyme Q10 crystal showing characteristic peaks at diffraction angles in 20±0.2° of 11.5°, 18.2°, 19.3°, 22.3°, 23.0° and 33.3° in powder Cu—Kα X-ray diffraction,
wherein the composition is in a solid form and the composition is at least one of food, nutritional functional food, specified health food, nutritious supplement, nutrient, animal drug, feed, cosmetic, medicament, treatment drug, prevention drug, and pet food.

2. The composition of claim 1 , further comprising:
at least one of an excipient, a disintegrator, a lubricant, a binder, an antioxidant, a colorant, an anticoagulation agent, an absorption promoter, and an active ingredient which is not reduced coenzyme Q10.

3. The composition of claim 2 , wherein the active ingredient is at least one of amino acid, vitamin, mineral, polyphenol, organic acid, saccharide, peptide, and protein.

4. The composition of claim 1 , which is in a form of a hard capsule.

5. The composition of claim 2 , which is in a form of a hard capsule.

6. The composition of claim 3 , which is in a form of a hard capsule.

7. The composition of claim 1 , which is in a form of a tablet.

8. The composition of claim 2 , which is in a form of a tablet.

9. The composition of claim 3 , which is in a form of a tablet.

10. The composition of claim 1 , which is in a form of a coated tablet.

11. The composition of claim 2 , which is in a form of a coated tablet.

12. The composition of claim 3 , which is in a form of a coated tablet.

Assignees

• Kaneka Corp

Inventors

• Kawachi Hideo
• Kitamura Shiro
• Ueda Yasuyoshi

Classifications

• A61P3/02

  Nutrients, e.g. vitamins, minerals · CPC title

• A23K20/111 Primary

  Aromatic compounds · CPC title

• A23L33/10

  using additives (addition of substantially indigestible substances A23L33/21) · CPC title

• A23V2002/00

  Food compositions, function of food ingredients or processes for food or foodstuffs · CPC title

• C07C46/10 Primary

  Separation; Purification; Stabilisation; Use of additives · CPC title