Reactive oxidative species generating materials and methods of use

Patent metadata

Field	Value
Publication number	US-9549951-B2
Application number	US-201614993324-A
Country	US
Kind code	B2
Filing date	Jan 12, 2016
Priority date	Aug 31, 2012
Publication date	Jan 24, 2017
Grant date	Jan 24, 2017

Abstract

Materials capable of delivering stabilized free radicals to targeted treatment sites. The materials comprise semi-crystalline, hydrolytically degradable polymers that are subjected to ionizing radiation to create stabilized free radicals therein. Upon exposure to oxygen containing aqueous media, the materials generate reactive oxidative species which are useful in biological processes.

First claim

What is claimed is:

1. A biocompatible device capable of releasing superoxide comprising:
a substrate; and
a biocompatible material comprising at least one semi-crystalline, hydrolytically degradable polymeric material, the polymeric material having been subjected to ionizing radiation at a dose rate less than about 50 kGy and sterilized by non-ionizing radiation methods; said polymeric material being in contact with at least a portion of said substrate,
wherein said at least one semi-crystalline, hydrolytically degradable polymeric material comprises a first polymeric material and a second polymeric material,
wherein at least one of said first and second polymeric materials comprises stabilized free radicals;
wherein said first polymeric material and said second polymeric material have been subjected to different doses of ionizing radiation, and
wherein the biocompatible material, upon contact with aqueous media, enable multi-phasic generation of reactive oxidative species.

2. A biocompatible device capable of releasing superoxide comprising:
a substrate; and
a biocompatible material comprising at least one semi-crystalline, hydrolytically degradable polymeric material, the polymeric material having been subjected to ionizing radiation while maintained in an inert atmosphere; said polymeric material being in contact with at least a portion of said substrate,
wherein said at least one semi-crystalline, hydrolytically, degradable polymeric material comprises a first polymeric material and a second polymeric material,
wherein at least one of said first and second polymeric materials comprises stabilized free radicals;
wherein said first polymeric material and said second polymeric material have been subjected to different doses of ionizing radiation, and
wherein the biocompatible material, upon contact with aqueous media, enable multi-phasic generation of reactive oxidative species.

3. The biocompatible device of claim 1 , wherein the first polymeric material has a different hydrolytic degradation rate than the second polymeric material.

4. The biocompatible device of claim 1 , wherein the first polymeric material has a different degree of crystallinity than the second polymeric material.

5. The biocompatible device of claim 1 , wherein the first polymeric material comprises a different amount of stabilized free radicals than the second polymeric material.

6. The biocompatible device of claim 1 , wherein at least one of said first and second polymeric materials is bioabsorbable.

7. The biocompatible device of claim 6 , wherein the bioabsorbable polymer is selected from the group consisting of poly(dioxanone), poly(glycolide), poly(lactide) poly(ε-caprolactone), poly(anhydrides) such as poly(sebacic acid), poly(hydroxyalkanoates) such as poly(3-hydroxybutyrate), copolymers of any of these and combinations thereof.

8. The biocompatible device of claim 2 , wherein the first polymeric material has a different hydrolytic degradation rate than the second polymeric material.

9. The biocompatible device of claim 2 , wherein the first polymeric material has a different degree of crystallinity than the second polymeric material.

10. The biocompatible device of claim 2 , wherein the first polymeric material comprises a different amount of stabilized free radicals than the second polymeric material.

11. The biocompatible device of claim 2 , wherein at least one of said first and second polymeric materials is bioabsorbable.

12. The biocompatible device of claim 11 , wherein the bioabsorbable polymer is selected from the group consisting of poly(dioxanone), poly(glycolide), poly(lactide) poly(ε-caprolactone), poly(anhydrides) such as poly(sebacic acid), poly(hydroxyalkanoates) such as poly(3-hydroxybutyrate), copolymers of any of these and combinations thereof.

Assignees

• Gore & Ass

Inventors

• Brown Tiffany J
• Lafleur Adam S
• Mazich Kenneth
• Towler Jeffrey C
• Zhang Ji

Classifications

• A61K33/40 Primary

  Peroxides · CPC title

• A61L27/54 Primary

  Biologically active materials, e.g. therapeutic substances {(A61L27/227 takes precedence)} · CPC title

• A61L2300/11

  Peroxy compounds, peroxides, e.g. hydrogen peroxide · CPC title

• A61L2/087

  Particle radiation, e.g. electron-beam, alpha or beta radiation · CPC title

• A61K41/0057 Primary

  Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent · CPC title