Methods and controllers for simulated moving bed chromatography for multicomponent separation

Patent metadata

Field	Value
Publication number	US-9534262-B2
Application number	US-201414228634-A
Country	US
Kind code	B2
Filing date	Mar 28, 2014
Priority date	Mar 28, 2013
Publication date	Jan 3, 2017
Grant date	Jan 3, 2017

Abstract

A system for reacting and separating solid and fluid components includes a series of sequential simulated moving bed (SMB) chromatography columns connected to form a circulation loop. Each SMB chromatography column includes an inlet and an outlet. A reactor is configured to receive a solid reactant and has an inlet and an outlet, and the reactor inlet is fluidly connected to an outlet of a first SMB chromatography column of the series of sequential SMB chromatography columns. The reactor outlet is fluidly connected to an inlet of a second SMB chromatography column of the series of sequential SMB chromatography columns.

First claim

That which is claimed is:

1. A system for reacting and separating solid and fluid components, the system comprising:
a series of sequential simulated moving bed (SMB) chromatography columns connected to form a circulation loop, each SMB chromatography column comprising an inlet and an outlet; and
a reactor configured to receive a solid reactant, the reactor having an inlet and an outlet, wherein the reactor inlet is fluidly connected to an outlet of a first SMB chromatography column of the series of sequential SMB chromatography columns, and the reactor outlet is fluidly connected to an inlet of a second SMB chromatography column of the series of sequential SMB chromatography columns.

2. The system of claim 1 , wherein the reactor comprises a first reactor, and the system further comprises a second reactor having an inlet and an outlet, wherein the second reactor inlet is fluidly connected to an outlet of a third SMB column of the series of sequential SMB columns, and the second reactor outlet is fluidly connected to an inlet of a fourth SMB column of the series of sequential SMB columns.

3. The system of claim 2 , wherein the first reactor comprises two or more reactors connected in a series.

4. The system of claim 3 , wherein the second reactor comprises two or more reactors connected in a series.

5. The system of claim 2 , wherein the first reactor and the second reactor are hydrolysis reactors.

6. The system of claim 5 , wherein a temperature of the first reactor is different than a temperature of the second reactor.

7. The system of claim 2 , further comprising a lignocellulosic biomass in the first reactor.

8. The system of claim 7 , wherein the first reactor is configured to react cellulose from a lignocellulosic biomass.

9. The system of claim 8 , wherein the second reactor is configured to react hemicelluloses from a lignocellulosic biomass.

10. The system of claim 9 , wherein the series of sequential SMB chromatography columns are configured to separate hemicellulosic sugars from biomass components of lignocellulosic biomass in the first and second reactors.

11. The system of claim 1 , wherein the reactor comprises two or more reactors connected in a series.

12. A method for separating materials from a reaction, the method comprising:
positioning a solid material in a reactor; the reactor having an inlet and an outlet; and
flowing a liquid through a series of sequential simulated moving bed (SMB) chromatography columns connected to form a circulation loop, each SMB chromatography column comprising an inlet and an outlet, wherein the reactor inlet is fluidly connected to an outlet of a first SMB chromatography column of the series of sequential SMB chromatography columns, and the reactor outlet is fluidly connected to an inlet of a second SMB chromatography column of the series of sequential SMB chromatography columns so that the liquid flowing through the series of sequential SMB chromatographic columns comprises at least one reaction product from the reactor.

13. The method of claim 12 , wherein the reactor comprises a first reactor, and a second reactor having an inlet and an outlet is fluidly connected to the series of SMB chromatographic columns so that the second reactor inlet is fluidly connected to an outlet of a third SMB column of the series of sequential SMB columns, and the second reactor outlet is fluidly connected to an inlet of a fourth SMB column of the series of sequential SMB columns.

14. The method of claim 13 , wherein the first reactor comprises two or more reactors connected in a series.

15. The method of claim 13 , wherein the second reactor comprises two or more reactors connected in a series.

16. The method of claim 13 , wherein the first reactor and the second reactor are hydrolysis reactors.

17. The method of claim 16 , wherein a temperature of the first reactor is different than a temperature of the second reactor.

18. The method of claim 13 , wherein the solid material comprises a lignocellulosic biomass.

19. The method of claim 18 , further comprising maintaining the first reactor under conditions sufficient to react cellulose from a lignocellulosic biomass.

20. The method of claim 19 , further comprising maintaining the second reactor under conditions sufficient to react hemicelluloses from a lignocellulosic biomass.

21. The method of claim 20 , further comprising separating hemicellulosic sugars from biomass components of lignocellulosic biomass in the first and second reactors and further separating hemicellulosic sugars from acid in the series of sequential SMB chromatography columns.

22. The method of claim 12 , wherein the reactor comprises two or more reactors connected in a series.

Assignees

• Georgia Tech Res Inst

Inventors

• Kawajiri Yoshiaki
• Realff Matthew J

Classifications

• C13B20/14 Primary

  using ion-exchange materials · CPC title

• C07H1/08

  from natural products · CPC title

• B01D15/1821

  Simulated moving beds · CPC title

• D21C1/00

  Pretreatment of the finely-divided materials before digesting (of waste paper D21C5/02) · CPC title

• C13K13/007

  Separation of sugars provided for in subclass C13K (C13K3/00 takes precedence) · CPC title