Regulatory b cells and their uses
US-2016375059-A1 · Dec 29, 2016 · US
Methods for eliminating at least a substantial portion of a clonal antigen-specific memory T cell subpopulation
US9528088B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9528088-B2 |
| Application number | US-201314086841-A |
| Country | US |
| Kind code | B2 |
| Filing date | Nov 21, 2013 |
| Priority date | Jun 28, 2002 |
| Publication date | Dec 27, 2016 |
| Grant date | Dec 27, 2016 |
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- Title
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Abstract
Official abstract text for this publication.
The present invention relates generally to methods for stimulating T cells, and more particularly, to methods to eliminate undesired (e.g., autoreactive, alloreactive, pathogenic) subpopulations of T cells from a mixed population of T cells, thereby restoring the normal immune repertoire of said T cells. The present invention also relates to compositions of cells, including stimulated T cells having restored immune repertoire and uses thereof.
First claim
Opening claim text (preview).
What is claimed is: 1. A method for activating and expanding naïve T cells present in a mixed population of T cells comprising naïve T cells and antigen-specific memory T cells, the method comprising: contacting the mixed population of T cells with a surface having attached thereto agents with binding activity to cell surface moieties on the surfaces of T cells in the mixed population, thereby (a) expanding naïve T cells, and (b) deleting antigen-specific memory T cells present in the mixed population of T cells, wherein the agents having binding affinity for CD3 protein complexes and CD28 proteins, and wherein the ratio of surface to cells is at least 5:1. 2. The method of claim 1 , wherein one or both of the agents are antibodies or an antibody fragments. 3. The method of claim 1 , wherein one of the agents is an anti-CD3 antibody or an anti-CD3 antibody fragment. 4. The method of claim 1 , wherein one of the agents is an anti-CD28 antibody or an anti-CD28 antibody fragment. 5. The method of claim 1 , wherein an anti-CD3 antibody or an anti-CD3 antibody fragment and an anti-CD28 antibody or an anti-CD28 antibody fragment are co-localized on the same surface. 6. The method of claim 1 , wherein the ratio of surface to cells is between 5:1 and 10:1.
Assignees
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Classifications
Drugs for immunological or allergic disorders · CPC title
Regulators of apoptosis · CPC title
- C12N5/0087Primary
Purging against subsets of blood cells, e.g. purging alloreactive T cells · CPC title
T cells · CPC title
Antigens related to auto-immune diseases; Preparations to induce self-tolerance · CPC title
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- What does patent US9528088B2 cover?
- The present invention relates generally to methods for stimulating T cells, and more particularly, to methods to eliminate undesired (e.g., autoreactive, alloreactive, pathogenic) subpopulations of T cells from a mixed population of T cells, thereby restoring the normal immune repertoire of said T cells. The present invention also relates to compositions of cells, including stimulated T cells h…
- Who is the assignee on this patent?
- Life Technologies Corp
- What technology area does this patent fall under?
- Primary CPC classification C12N5/0087. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Dec 27 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).