Protective vaccine based on Staphylococcus aureus SA2451 protein

Patent metadata

Field	Value
Publication number	US-9527892-B2
Application number	US-201214354948-A
Country	US
Kind code	B2
Filing date	Oct 26, 2012
Priority date	Oct 31, 2011
Publication date	Dec 27, 2016
Grant date	Dec 27, 2016

Abstract

The present invention relates to methods of inducing an immune response to Staphylococcus comprising administering a composition comprising an SA2451-related polypeptide from Staphylococcus aureus as well as derivatives or fragments thereof. The present invention also encompasses methods of treating and/or reducing the likelihood of a Staphylococcus infection by administering a composition comprising an SA2451-related polypeptide or an antibody that specifically binds to an SA2451 polypeptide, derivative or fragments thereof. Compositions administered in the methods of the invention can include one or more additional antigens. Compositions used to practice the methods of the invention are also encompassed.

First claim

What is claimed is:

1. A method of inducing an immune response in a patient against Staphylococcus aureus infection comprising administering an immunologically effective amount of the polypeptide of SEQ ID NO: 1, a pharmaceutically acceptable carrier and an adjuvant.

2. The method of claim 1 wherein the patient is human or a non-human mammal.

3. The method of claim 2 wherein the patient has weakened immunity, has received a foreign body implant or is on renal dialysis.

4. The method of claim 3 wherein the patient that has weakened immunity has a Human Immunodeficiency Virus (HIV) infection or Acquired Immune Deficiency Syndrome (AIDS).

5. The method of claim 3 wherein the foreign body implant is a catheter, a vascular device, pacemaker leads, defibrillator systems, or prosthetic heart valve.

6. The method of claim 1 , wherein the composition further comprises one or more additional S. aureus antigens.

Assignees

• Merck Sharp & Dohme

Inventors

• Mcneely Tessie
• Montgomery Donna Lorraine
• Cope Leslie
• Joshi Amita
• Pancari Gregory P
• Fan Hongxia

Classifications

• A61K39/085 Primary

  Staphylococcus · CPC title

• A61K2039/505

  comprising antibodies · CPC title

• A61K38/00

  Medicinal preparations containing peptides (peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00) · CPC title

• A61K8/99

  from microorganisms other than algae or fungi, e.g. protozoa or bacteria · CPC title

• A61K39/00

  Medicinal preparations containing antigens or antibodies (materials for immunoassay G01N33/53) · CPC title