Preparation of (R,R)-fenoterol and (R,R)-or (R,S)-fenoterol analogues and their use in treating congestive heart failure

Patent metadata

Field	Value
Publication number	US-9522871-B2
Application number	US-201414199208-A
Country	US
Kind code	B2
Filing date	Mar 6, 2014
Priority date	Aug 10, 2006
Publication date	Dec 20, 2016
Grant date	Dec 20, 2016

Abstract

This disclosure concerns the discovery of (R,R)- and (R,S)-fenoterol analogues which are highly effective at binding β2-adrenergic receptors. Exemplary chemical structures for these analogues are provided. Also provided are pharmaceutical compositions including the disclosed (R,R)-fenoterol and fenoterol analogues, and methods of using such compounds and compositions for the treatment of cardiac disorders such as congestive heart failure and pulmonary disorders such as asthma or chronic obstructive pulmonary disease.

First claim

We claim:

1. A compound having the name (R,R′)-4-methoxy-ethylfenoterol.

Assignees

• Us Health

Inventors

• Wainer Irving William
• Zhu Weizhong
• Chakir Khalid
• Xiao Rui-Ping
• Abernethy Darrell R
• Beigi Abhari Farideh M

Classifications

• A61P9/10

  for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis · CPC title

• A61P9/04

  Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure · CPC title

• A61P9/00

  Drugs for disorders of the cardiovascular system · CPC title

• A61P11/00

  Drugs for disorders of the respiratory system · CPC title

• A61P11/06

  Antiasthmatics · CPC title