Preparation of (R,R)-fenoterol and (R,R)- or (R,S)-fenoterol analogues and their use in treating congestive heart failure

Patent metadata

Field	Value
Publication number	US-10308591-B2
Application number	US-201815874747-A
Country	US
Kind code	B2
Filing date	Jan 18, 2018
Priority date	Aug 10, 2006
Publication date	Jun 4, 2019
Grant date	Jun 4, 2019

Abstract

This disclosure concerns the discovery of (R,R)- and (R,S)-fenoterol analogs which are highly effective at binding β2-adrenergic receptors. Exemplary chemical structures for these analogs are provided. Also provided are pharmaceutical compositions including the disclosed (R,R)-fenoterol and fenoterol analogs, and methods of using such compounds and compositions for the treatment of cardiac disorders such as congestive heart failure and pulmonary disorders such as asthma or chronic obstructive pulmonary disease.

First claim

We claim:

1. A method for treating congestive heart failure in a subject, comprising:
administering to the subject with the cardiovascular disorder a therapeutically effective amount of a compound having the formula

2. The method of claim 1 , wherein the compound is

3. The method of claim 1 , wherein administering a therapeutically effective amount of the compound comprises administering a pharmaceutical composition comprising the therapeutically effective amount of the compound and at least one pharmaceutically acceptable carrier.

4. The method of claim 1 , wherein administering the therapeutically effective amount of the compound to the subject increases cardiomyocyte contractility.

Assignees

• Us Health

Inventors

• Wainer Irving William
• Zhu Weizhong
• Chakir Khalid
• Xiao Rui-Ping
• Abernethy Darrell R
• Beigi Abhari Farideh M

Classifications

• A61P9/04

  Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure · CPC title

• A61P9/00

  Drugs for disorders of the cardiovascular system · CPC title

• A61P9/10

  for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis · CPC title

• A61P11/06

  Antiasthmatics · CPC title

• A61P11/00

  Drugs for disorders of the respiratory system · CPC title