Microchannel with an opening and/or closing and/or pumping device

Patent metadata

Field	Value
Publication number	US-9512935-B2
Application number	US-201314376432-A
Country	US
Kind code	B2
Filing date	Feb 22, 2013
Priority date	Feb 24, 2012
Publication date	Dec 6, 2016
Grant date	Dec 6, 2016

Abstract

A microchannel formed at the interface of two layers of material, at least one of the two materials being a substrate. A volume of the microchannel contains a film of polymer fixed by covalent bonding to the substrate layer. The film of polymer being formed from a hydrogel material susceptible to undergoing changes in volume under the action of an external stimulus. The hydrogel polymer is chosen from those which are sensitive to changes in temperature, light, electrical field or pH. A method for producing the microchannel.

First claim

The invention claimed is:

1. A microchannel formed at the interface of two layers of material, a volume of said microchannel containing a film, said film being formed from a hydrogel type polymer material that is configured to undergo volume changes under an external stimulus action, wherein said film is grafted by covalent bonding on a substrate provided by one of the two material layers, wherein said film's substrate is flat and spans an entire width of said microchannel, and wherein said film is configured to reversibly modify a hydrodynamic resistance of said microchannel by undergoing said volume changes perpendicularly to said film's substrate.

2. The microchannel as claimed in claim 1 , wherein the polymer of the hydrogel type is sensitive to variations of temperature, light, electric field or pH.

3. A microfluidic system comprising at least one microchannel as claimed in claim 1 .

4. A method for fabricating a microchannel, comprising the steps of:
grafting a polymer film on a substrate by covalent bonding;
forming said microchannel at an interface of two layers of material, at least one of the two material layers providing said substrate for said polymer film, such that a volume of said microchannel contains said polymer film;
wherein the polymer is a hydrogel type material that undergoes volume changes under an external stimulus action;
wherein the step of grafting the polymer film of the hydrogel type on the substrate is performed prior to the step of forming said microchannel;
wherein said polymer film's substrate is flat and spans an entire width of said microchannel; and
wherein said volume changes occur perpendicularly to said polymer film's substrate, and the polymer film reversibly modifies a hydrodynamic resistance of said microchannel.

5. The method as claimed in claim 4 , wherein the step of grafting comprises the steps of chemically modifying the polymer of the hydrogel type and modifying surface chemical properties of the substrate.

6. The method as claimed in claim 5 , wherein the step of chemically modifying the polymer comprises the step of amidating the polymer by means of an amine bearing at least one vinyl group.

7. The method as claimed in claim 5 , further comprising the step of synthesizing the polymer of the hydrogel type prior to the step of grafting.

8. The method as claimed in claim 4 , further comprising the step of synthesizing the polymer of the hydrogel type prior to the step of grafting.

9. The method as claimed in claim 8 , further comprising the step of synthesizing the polymer by crosslinking between functionalized polymer chains synthesized by radical copolymerization.

10. The microchannel of claim 1 , wherein said microchannel is configured to be opened and closed reversibly by the volume changes of said film.

11. The microchannel of claim 1 , wherein said microchannel is configured to be opened and closed by the volume changes of said film to displace a fluid.

Assignees

• Fonds Espci Georges Charpak
• Centre Nat Rech Scient
• Centre Nat De La Rech

Inventors

• Vergne Clemence
• Tabeling Patrick
• Tran Yvette
• Monti Fabrice
• Devys Lucie

Classifications

• F16K99/0026 Primary

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• B01L7/52

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• B01L2400/0677

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