Antibody drug for prevention or treatment of autoimmune diseases
US-2024352108-A1 · Oct 24, 2024 · US
Assays for the detection of anti-TNF drugs and autoantibodies
US9506920B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9506920-B2 |
| Application number | US-201414336955-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jul 21, 2014 |
| Priority date | Oct 26, 2009 |
| Publication date | Nov 29, 2016 |
| Grant date | Nov 29, 2016 |
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Abstract
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The present invention provides assays for detecting and measuring the presence or level of anti-TNFα drug therapeutics and autoantibodies in a sample. The present invention is useful for optimizing therapy and monitoring patients receiving anti-TNFα drug therapeutics to detect the presence or level of autoantibodies (e.g., HACA and/or HAHA) against the drug.
First claim
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What is claimed is: 1. A method for determining the presence or level of an autoantibody to a therapeutic antibody for treating an autoimmune disease in a sample, the method comprising: (a) contacting a labeled therapeutic antibody with the sample to form a labeled complex with the autoantibody; (b) subjecting the labeled complex to size exclusion chromatography to separate the labeled complex from free labeled therapeutic antibody and to detect an amount of the labeled complex…
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Frequently asked questions
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- What does patent US9506920B2 cover?
- The present invention provides assays for detecting and measuring the presence or level of anti-TNFα drug therapeutics and autoantibodies in a sample. The present invention is useful for optimizing therapy and monitoring patients receiving anti-TNFα drug therapeutics to detect the presence or level of autoantibodies (e.g., HACA and/or HAHA) against the drug.
- Who is the assignee on this patent?
- Nestec Sa
- What technology area does this patent fall under?
- Primary CPC classification G01N33/564. Mapped technology areas include Physics.
- When was this patent published?
- Publication date Tue Nov 29 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).