Prodrugs of fumarates and their use in treating various diseases

Patent metadata

Field	Value
Publication number	US-9505776-B2
Application number	US-201414212745-A
Country	US
Kind code	B2
Filing date	Mar 14, 2014
Priority date	Mar 14, 2013
Publication date	Nov 29, 2016
Grant date	Nov 29, 2016

Abstract

The present invention provides compounds of formula (I), and pharmaceutical compositions thereof.

First claim

What is claimed:

1. A compound of Formula (Ia), or a pharmaceutically acceptable salt thereof:

wherein:
R 1 is unsubstituted C 1 -C 6 alkyl;
L a is unsubstituted C 1 -C 6 alkyl linker; and
R 2 is H, unsubstituted C 1 -C 6 alkyl, unsubstituted C 2 -C 6 alkenyl, or unsubstituted C 2 -C 6 alkynyl.

2. The compound of claim 1 , wherein R 1 is methyl.

3. The compound of claim 1 , wherein L a is an unsubstituted C 1 -C 3 alkyl.

4. The compound of claim 1 , wherein L a is an unsubstituted C 2 alkyl.

5. The compound of claim 1 , wherein R 2 is an unsubstituted C 1 -C 3 alkyl.

6. The compound of claim 1 , wherein R 2 is an unsubstituted C 1 -C 2 alkyl.

7. The compound of claim 1 , wherein R 2 is methyl.

8. The compound of claim 1 , having structure:

Assignees

• Alkermes Pharma Ireland Ltd

Inventors

• Zeidan Tarek A
• Duncan Scott
• Hencken Christopher P
• Wynn Thomas Andrew
• Sanrame Carlos N

Classifications

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P25/00

  Drugs for disorders of the nervous system · CPC title

• A61P17/06

  Antipsoriatics · CPC title

• C07C233/18

  having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton · CPC title

• C07D207/404

  with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide · CPC title