Modular flow injection analysis system

Patent metadata

Field	Value
Publication number	US-9494613-B2
Application number	US-201013375968-A
Country	US
Kind code	B2
Filing date	May 18, 2010
Priority date	Jun 4, 2009
Publication date	Nov 15, 2016
Grant date	Nov 15, 2016

Abstract

A modular flow injection analysis system has a sample connection, a reagent inflow and a media discharge. The analysis system is formed of a plurality of functional modules stacked one on top of the other. These functional modules include a metering module including a metering channel having an inlet and an outlet, a mixing module including a mixing channel having an inlet and an outlet, an analysis module including a media chamber connected to the outlet of the mixing channel, and a media control module. The modules are connected by aligned media channels. These media channels replace the conventional tube connections. They are connected automatically when the modules are fitted together.

First claim

The invention claimed is:

1. A modular flow injection analysis system comprising a sample inflow, a reagent inflow and a media discharge, formed of a plurality of functional modules which are stacked one on top of the other and at least include:
a) a metering module including a metering channel having an inlet and an outlet;
b) a mixing module including a mixing channel having an inlet and an outlet;
c) an analysis module including a media chamber connected to the outlet of the mixing channel;
d) a media control module;
characterized in that:
the metering channel having a length and a cross-section determining the amount of the reagent supplied;
the modules have passage openings which are all in alignment with each other to define a continuous media channel by which the modules are connected and the media channel is connected to a sample connection;
the media control module selectively connects one of the sample inflow and the reagent inflow to the inlet of the metering channel of the metering module by a valve control;
the media control module selectively connects the outlet of the metering channel to one of the inlet of the mixing channel and a reagent discharge by a valve control; and
the media control module operable to measure out a specific quantity of reagent by controlling the reagent inflow to the inlet of the metering channel and connecting the outlet of the metering channel to the reagent discharge for a period of time to ensure that the metering channel is completely filled with the reagent.

2. The modular flow injection analysis system according to claim 1 , further comprising a media connection module which includes the sample connection and the media discharge.

3. The modular flow injection analysis system according to claim 1 , wherein the media control module includes a reagent connection.

4. The modular flow injection analysis system according to claim 1 , wherein a sealing plate is inserted between the metering module and the mixing module, the sealing plate having passage openings for the media channels of the modules.

5. The modular flow injection analysis system according to claim 1 , wherein the metering module is in the form of a plate which has the metering channel recessed therein in a meander shape.

6. The modular flow injection analysis system according to claim 1 , wherein the mixing module is in the form of a plate which has the mixing channel recessed therein in a meander shape.

7. The modular flow injection analysis system according to claim 1 , wherein a sealing plate is inserted between the mixing module and the analysis module, the sealing plate having passage openings for the media channels of the modules.

8. The modular flow injection analysis system according to any of the preceding claims, wherein the media control module includes a 3/2-way valve which connects the inlet of the metering channel with one of the sample inflow and the reagent inflow.

9. The modular flow injection analysis system according to claim 1 , wherein the media control module includes a 3/2-way valve which connects the outlet of the metering channel with one of the inlet of the mixing channel and the reagent discharge.

10. The modular flow injection analysis system according to claim 1 , wherein the media chamber of the analysis module is traversed by at least one of an optical, electrochemical and physical measuring path.

11. The modular flow injection analysis system according to claim 2 , wherein the metering module is arranged adjacent to the media control module and the analysis module is arranged adjacent to the media connection module, at least one media channel being guided proceeding from the media connection module to the media control module and traversing all intermediate modules.

12. The modular flow injection analysis system according to claim 1 , wherein the entirety of the modules stacked one on top of the other constitutes a cuboid or cube-shaped block.

13. The modular flow injection analysis system according to claim 1 , wherein the modules stacked one on top of the other have recesses which are aligned with each other and jointly form a receiving space.

14. The modular flow injection analysis system according to claim 1 , wherein the reagent connection and the sample connection are interchangeable as required.

15. The modular flow injection analysis system according to claim 1 , wherein a plurality of mixing modules is arranged in series and provided with separate reagent connections.

16. The modular flow injection analysis system according to claim 1 , comprising an additional connection module which is arranged downstream in series with a mixing module and establishes a media connection to a separate module block.

17. The modular flow injection analysis system according to claim 16 , wherein the separate module block includes a further mixing module and an analysis module.

18. The modular flow injection analysis system according to claim 2 , wherein the media control module includes a reagent connection.

Assignees

• Oberndorfer Christian
• Winkler Michael
• Zuern Marco
• Buerkert Werke Gmbh

Inventors

• Oberndorfer Christian
• Winkler Michael
• Zuern Marco

Classifications

• G01N2035/00326

  Analysers with modular structure · CPC title

• B01J2219/00889

  Mixing · CPC title

• B01L3/502738

  characterised by integrated valves (throttle valves in microfluidic sample containers B01L3/502746) · CPC title

• B01J2219/00891

  Feeding or evacuation · CPC title

• B01L3/502715

  characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces · CPC title