N-maleimidyl polymer derivatives
US-9169350-B2 · Oct 27, 2015 · US
US9493609B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9493609-B2 |
| Application number | US-201514865362-A |
| Country | US |
| Kind code | B2 |
| Filing date | Sep 25, 2015 |
| Priority date | Feb 22, 2000 |
| Publication date | Nov 15, 2016 |
| Grant date | Nov 15, 2016 |
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The invention is directed to multi-functional N-maleimidyl polymer derivatives comprising a water soluble and non-peptidic polymer backbone having a terminal carbon, such as a poly(alkylene glycol), the terminal carbon of the polymer backbone being directly bonded to the nitrogen atom of a N-maleimidyl moiety without a linking group therebetween. The invention also provides two methods of preparing such linkerless N-maleimidyl polymer derivatives.
Opening claim text (preview).
That which is claimed is: 1. A multi-functional N-maleimidyl polymer derivative having the formula: wherein: X is aldehyde; and n is about 20 to about 4000.
Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers · CPC title
obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin · CPC title
Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule · CPC title
Polymers modified by chemical after-treatment · CPC title
cyclic · CPC title
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