Bordetella outer-membrane protein antigens and methods of making and using the same
US-9283268-B2 · Mar 15, 2016 · US
Bordetella outer-membrane protein antigens and methods of making and using the same
US9486514B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9486514-B2 |
| Application number | US-201615014665-A |
| Country | US |
| Kind code | B2 |
| Filing date | Feb 3, 2016 |
| Priority date | Oct 25, 2007 |
| Publication date | Nov 8, 2016 |
| Grant date | Nov 8, 2016 |
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Abstract
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An isolated protein or peptide selected from the group consisting of Bordetella colonization factor A (BcfA) protein and antigenic fragments thereof is described, along with an isolated nucleic acid encoding the same, antibodies that bind to the same, methods of producing an immune response in a mammalian subject in need thereof by administering the proteins, peptides or antibodies, and pharmaceutical compositions comprising the same.
First claim
Opening claim text (preview).
That which is claimed is: 1. A method of producing an immune response in a mammalian subject in need thereof, comprising administering to said subject an isolated protein or peptide comprising (i) the Bordetella colonization factor A (BcfA) protein of SEQ ID NO: 2 or (ii) and antigenic fragments thereof comprising 20 or more contiguous amino acids thereof, in an amount effective to produce an immune response. 2. The method of claim 1 , wherein said protein or peptide is an antigenic fragment of BcfA having the sequence given herein as SEQ ID NO: 3 or an antigenic fragment comprising 20 or more contiguous amino acids thereof. 3. The method of claim 1 , wherein said administering further comprises an adjuvant. 4. The method of claim 1 , wherein said administering delivers said BcfA protein or peptide by a mucosal route. 5. The method of claim 1 , wherein said administering delivers said BcfA protein or peptide by a parenteral route. 6. The method of claim 1 , wherein said administering delivers said BcfA protein or peptide by a transdermal route. 7. The method of claim 1 , wherein said administering delivers said effective amount of BcfA protein or peptide in a single dose schedule. 8. The method of claim 1 , wherein said administering delivers said effective amount of BcfA protein or peptide in a multiple dose schedule. 9. A method of producing an immune response in a mammalian subject in need thereof, comprising administering to said subject an isolated Bordetella colonization factor A (BcfA) peptide comprising an antigenic fragment of 20 or more contiguous amino acids of SEQ ID NO: 2 in an amount effective to produce an immune response. 10. The method of claim 9 , wherein said administering further comprises an adjuvant. 11. The method of claim 9 , wherein said administering delivers said BcfA peptide antigenic fragment by a mucosal route. 12. The method of claim 9 , wherein said administering delivers said BcfA peptide antigenic fragment by a parenteral route. 13. The method of claim 9 , wherein said administering delivers said BcfA peptide antigenic fragment by a transdermal route. 14. The method of claim 9 , wherein said administering delivers said effective amount of BcfA peptide antigenic fragment in a single dose schedule. 15. The method of claim 9 , wherein said administering delivers said effective amount of BcfA peptide antigenic fragment in a multiple dose schedule.
Assignees
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Classifications
from Bordetella (G) · CPC title
humoral response · CPC title
Bacteria · CPC title
- A61K39/099Primary
Bordetella · CPC title
Immunostimulants · CPC title
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- What does patent US9486514B2 cover?
- An isolated protein or peptide selected from the group consisting of Bordetella colonization factor A (BcfA) protein and antigenic fragments thereof is described, along with an isolated nucleic acid encoding the same, antibodies that bind to the same, methods of producing an immune response in a mammalian subject in need thereof by administering the proteins, peptides or antibodies, and pharm…
- Who is the assignee on this patent?
- Univ Wake Forest Health Sciences
- What technology area does this patent fall under?
- Primary CPC classification A61K39/099. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Nov 08 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 1 related publication on this page (citations in our corpus or others sharing the same primary CPC).