Pharmaceutical combination and use thereof
US-2024189341-A1 · Jun 13, 2024 · US
US9283268B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9283268-B2 |
| Application number | US-201414498537-A |
| Country | US |
| Kind code | B2 |
| Filing date | Sep 26, 2014 |
| Priority date | Oct 25, 2007 |
| Publication date | Mar 15, 2016 |
| Grant date | Mar 15, 2016 |
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An isolated protein or peptide selected from the group consisting of Bordetella colonization factor A (BcfA) protein and antigenic fragments thereof is described, along with an isolated nucleic acid encoding the same, antibodies that bind to the same, methods of producing an immune response in a mammalian subject in need thereof by administering the proteins, peptides or antibodies, and pharmaceutical compositions comprising the same.
Opening claim text (preview).
That which is claimed is: 1. A method of treating a mammalian subject for a Bordetella infection, comprising administering said subject an antibody in a treatment effective amount, wherein said antibody binds to Bordetella colonization factor A (BcfA) protein fragment consisting of 20 to 500 consecutive amino acids of either SEQ ID NO: 2 or SEQ ID NO:3. 2. The method of claim 1 , wherein said Bordetella infection is a Bordetella bronchiseptica or Bordetella pertussis infection. 3. The method of claim 1 , wherein said Bordetella infection is a Bordetella bronchiseptica infection. 4. The method of claim 1 , wherein said Bordetella infection is a Bordetella pertussis infection.
from Bordetella (G) · CPC title
humoral response · CPC title
Antibacterial agents · CPC title
Immunostimulants · CPC title
Bordetella · CPC title
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