Fibronectin based scaffold domain proteins that bind to myostatin
US-2015231211-A1 · Aug 20, 2015 · US
Fc fusion proteins comprising novel linkers or arrangements
US9469676B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9469676-B2 |
| Application number | US-201214111327-A |
| Country | US |
| Kind code | B2 |
| Filing date | Apr 13, 2012 |
| Priority date | Apr 13, 2011 |
| Publication date | Oct 18, 2016 |
| Grant date | Oct 18, 2016 |
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- Title
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- Abstract
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Abstract
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The application provides Fc fusion proteins having novel arrangements. In one embodiment, the application provides Fc fusion proteins comprising a 10 Fn3 domain. In another embodiment, the application provides Fc fusion proteins comprising linkers derived from the naturally occurring C-terminal tail regions of membrane bound or secretory immunoglobulins.
First claim
Opening claim text (preview).
The invention claimed is: 1. A polypeptide comprising an immunoglobulin IgG Fc domain and a heterologous polypeptide, wherein the heterologous polypeptide is fused to the N-terminus or the C-terminus of the Fc domain by a polypeptide linker, wherein the polypeptide linker comprises an amino acid sequence selected from the group consisting of SEQ ID NOs: 51-54, 63-65 and 84. 2. The polypeptide of claim 1 , wherein the polypeptide linker comprises SEQ ID NO: 84. 3. The polypeptide of claim 1 , wherein the heterologous polypeptide is fused to the C-terminus of the Fc domain. 4. The polypeptide of claim 1 , wherein the heterologous polypeptide is fused to the N-terminus of the Fc domain. 5. The polypeptide of claim 1 , wherein the heterologous polypeptide comprises a 10 Fn3 domain. 6. The polypeptide of claim 1 , wherein the immunoglobulin Fc domain comprises a hinge or a portion thereof. 7. The polypeptide of claim 1 , wherein the polypeptide linker consists of an amino acid sequence selected from the group consisting of SEQ ID NOs: 51-54, 63-65 and 84.
Assignees
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Classifications
- C07K14/78Primary
Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG] · CPC title
Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value · CPC title
against receptors for growth factors, growth regulators · CPC title
against enzymes · CPC title
Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto · CPC title
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- What does patent US9469676B2 cover?
- The application provides Fc fusion proteins having novel arrangements. In one embodiment, the application provides Fc fusion proteins comprising a 10 Fn3 domain. In another embodiment, the application provides Fc fusion proteins comprising linkers derived from the naturally occurring C-terminal tail regions of membrane bound or secretory immunoglobulins.
- Who is the assignee on this patent?
- Camphausen Ray, Saeed-Kothe Amna, Davis Jonathan, and 2 more
- What technology area does this patent fall under?
- Primary CPC classification C07K14/78. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Oct 18 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 7 related publications on this page (citations in our corpus or others sharing the same primary CPC).