Fibronectin based scaffold domain proteins that bind to myostatin

Patent metadata

Field	Value
Publication number	US-8933199-B2
Application number	US-201314025253-A
Country	US
Kind code	B2
Filing date	Sep 12, 2013
Priority date	Sep 13, 2012
Publication date	Jan 13, 2015
Grant date	Jan 13, 2015

Abstract

The present invention relates to fibronectin-based scaffold domain proteins that bind to myostatin. The invention also relates to the use of these proteins in therapeutic applications to treat muscular dystrophy, cachexia, sarcopenia, osteoarthritis, osteoporosis, diabetes, obesity, COPD, chronic kidney disease, heart failure, myocardial infarction, and fibrosis. The invention further relates to cells comprising such proteins, polynucleotides encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the proteins.

First claim

We claim:

1. A polypeptide comprising a fibronectin type III tenth ( 10 Fn3) domain which binds to myostatin and comprises the amino acid sequence of SEQ ID NO: 6, wherein (Z) x , (Z) y and (Z) z comprise:
(a) the amino acid sequences of SEQ ID NOs: 7, 39 and 46, respectively
(b) the amino acid sequences of SEQ ID NOs: 8, 40 and 47, respectively;
(c) the amino acid sequences of SEQ ID NOs: 12, 42 and 51, respectively;
(d) the amino acid sequences of SEQ ID NOs: 17, 39 and…

Assignees

• Bristol Myers Squibb Co

Inventors

• Cload Sharon
• Engle Linda
• Lipovsek Dasa
• Madireddi Malavi
• Rakestraw Ginger Chao
• Swain Joanna
• Zhao Wenjun
• Corbett Martin J
• Kozhich Alexander T

Classifications

• A61P5/50

  Human Necessities · mapped topic

• A61P3/06

  Human Necessities · mapped topic

• A61P3/10

  Human Necessities · mapped topic

• A61P7/12

  Human Necessities · mapped topic

• A61P9/10

  Human Necessities · mapped topic