Compositions and methods for the treatment of inflammation and pain

Patent metadata

Field	Value
Publication number	US-9464051-B2
Application number	US-201615083319-A
Country	US
Kind code	B2
Filing date	Mar 29, 2016
Priority date	Dec 7, 2013
Publication date	Oct 11, 2016
Grant date	Oct 11, 2016

Abstract

The invention relates to the compounds of formula V or its pharmaceutical acceptable polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula V and methods for the treatment of inflammation and pain may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, lozenge, spray, intravenous, oral solution, buccal mucosal layer tablet, parenteral administration, syrup, or injection. Such compositions may be used to treatment of pain, oral mucosal inflammatory or oral infectious diseases.

First claim

What is claimed is:

1. A compound represented by:

2. A pharmaceutical composition comprising the compound of claim 1 and a pharmaceutically acceptable carrier.

3. The pharmaceutical composition of claim 2 , wherein said pharmaceutical composition is formulated to treat inflammation mediated pain in a patient in need thereof with an effective amount of said pharmaceutical composition, and wherein said pharmaceutical composition is administered to the patient in need by lozenge, spray, oral administration, delayed release or sustained release, transmucosal administration, syrup, mucoadhesive, buccal formulation, mucoadhesive tablet, topical administration, parenteral administration, injection, subdermal administration, oral solution, rectal administration, buccal administration or transdermal administration.

4. The pharmaceutical composition of claim 3 , wherein said inflammation mediated pain is caused by oral mucositis, oral ulceration, oral inflammation, oral infection, oral wounds, dental surgery, post-tosillectomy, odontostomatology, gingivitis, stomatitis, glossitis, aphthous ulcers, pharyngitis, tonsillitis, radiation or intubation mucositis.

5. A method of treating mucositis or pain, wherein the method comprises administering to a patient in need thereof a therapeutically effective amount of the pharmaceutical composition of claim 2 , and wherein said pharmaceutical composition is administered to the patient in need by oral administration, delayed release or sustained release, transmucosal administration, syrup, lozenge, spray, mucoadhesive, buccal formulation, mucoadhesive tablet, topical administration, parenteral administration, injection, subdermal administration, oral solution, rectal administration, buccal administration or transdermal administration.

6. A method of treating pain of claim 5 , wherein the pain is associated with mucositis, dental surgery, oral ulceration, post-tosillectomy, odontostomatology, gingivitis, stomatitis, glossitis, aphthous ulcers, oral ulceration, pharyngitis, tonsillitis, radiation or intubation mucositis.

7. A compound represented by:

8. A pharmaceutical composition comprising the compound of claim 7 and a pharmaceutically acceptable carrier.

9. The pharmaceutical composition of claim 8 , wherein said pharmaceutical composition is formulated to treat inflammation mediated pain in a patient in need thereof with an effective amount of said pharmaceutical composition, and wherein said pharmaceutical composition is administered to the patient in need by lozenge, spray, oral administration, delayed release or sustained release, transmucosal administration, syrup, mucoadhesive, buccal formulation, mucoadhesive tablet, topical administration, parenteral administration, injection, subdermal administration, oral solution, rectal administration, buccal administration or transdermal administration.

10. The pharmaceutical composition of claim 9 , wherein said inflammation mediated pain is caused by oral mucositis, oral ulceration, oral inflammation, oral infection, oral wounds, dental surgery, post-tosillectomy, odontostomatology, gingivitis, stomatitis, glossitis, aphthous ulcers, pharyngitis, tonsillitis, radiation or intubation mucositis.

11. A method of treating mucositis or pain, wherein the method comprises administering to a patient in need thereof a therapeutically effective amount of the pharmaceutical composition of claim 8 , and wherein said pharmaceutical composition is administered to the patient in need by oral administration, delayed release or sustained release, transmucosal administration, syrup, lozenge, spray, mucoadhesive, buccal formulation, mucoadhesive tablet, topical administration, parenteral administration, injection, subdermal administration, oral solution, rectal administration, buccal administration or transdermal administration.

12. A method of treating pain of claim 11 , wherein the pain is associated with mucositis, dental surgery, oral ulceration, post-tosillectomy, odontostomatology, gingivitis, stomatitis, glossitis, aphthous ulcers, oral ulceration, pharyngitis, tonsillitis, radiation or intubation mucositis.

13. A compound represented by:

14. A pharmaceutical composition comprising the compound of claim 13 and a pharmaceutically acceptable carrier.

15. The pharmaceutical composition of claim 14 , wherein said pharmaceutical composition is formulated to treat inflammation mediated pain in a patient in need thereof with an effective amount of said pharmaceutical composition, and wherein said pharmaceutical composition is administered to the patient in need by lozenge, spray, oral administration, delayed release or sustained release, transmucosal administration, syrup, mucoadhesive, buccal formulation, mucoadhesive tablet, topical administration, parenteral administration, injection, subdermal administration, oral solution, rectal administration, buccal administration or transdermal administration.

16. The pharmaceutical composition of claim 15 , wherein said inflammation mediated pain is caused by oral mucositis, oral ulceration, oral inflammation, oral infection, oral wounds, dental surgery, post-tosillectomy, odontostomatology, gingivitis, stomatitis, glossitis, aphthous ulcers, pharyngitis, tonsillitis, radiation or intubation mucositis.

17. A method of treating mucositis or pain, wherein the method comprises administering to a patient in need thereof a therapeutically effective amount of the pharmaceutical composition of claim 14 , and wherein said pharmaceutical composition is administered to the patient in need by oral administration, delayed release or sustained release, transmucosal administration, syrup, lozenge, spray, mucoadhesive, buccal formulation, mucoadhesive tablet, topical administration, parenteral administration, injection, subdermal administration, oral solution, rectal administration, buccal administration or transdermal administration.

18. A method of treating pain of claim 17 , wherein the pain is associated with mucositis, dental surgery, oral ulceration, post-tosillectomy, odontostomatology, gingivitis, stomatitis, glossitis, aphthous ulcers, oral ulceration, pharyngitis, tonsillitis, radiation or intubation mucositis.

Assignees

• Kandula Mahesh
• Cellix Bio Private Ltd

Inventors

• Kandula Mahesh

Classifications

• C07C53/126

  Acids containing more than four carbon atoms · CPC title

• A61P29/00

  Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] · CPC title

• C07D233/50 Primary

  with carbocyclic radicals directly attached to said nitrogen atoms · CPC title

• C07D233/06

  with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms · CPC title

• C07C237/04

  the carbon skeleton being acyclic and saturated · CPC title