Molecular design toward dual-modality probes for radioisotope-based imaging (PET or SPECT) and MRI

Patent metadata

Field	Value
Publication number	US-9463254-B2
Application number	US-201414298688-A
Country	US
Kind code	B2
Filing date	Jun 6, 2014
Priority date	Jun 7, 2013
Publication date	Oct 11, 2016
Grant date	Oct 11, 2016

Abstract

In some aspects, the present invention provides novel ligands, which may be used to make novel dual-modality imaging agents, for example, for PET and MRI imaging. In further aspects, by the present disclosure also provides methods of use and methods of preparation of the novel ligands, metal complexes, and imaging agents thereof.

First claim

What is claimed:

1. A compound of the formula:

wherein:
R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are each independently selected from

X 1 , X 2 , and X 3 are each independently alkanediyl (C≦12) , alkenediyl (C≦12) , alkynediyl (C≦12) , arenediyl (C≦12) , heteroarenediyl (C≦12) , alkoxydiyl (C≦12) , alkylaminodiyl (C≦12) , or a substituted version of any of these groups; or
an amino acid residue, an amino acid residue linked to a targeting moiety, a PEG linker comprising between 2 and 200 repeating units;
Y 1 , Y 2 , Y 3 , Y 4 , Y 5 , and Y 6 are each independently alkanediyl (C≦12) , alkenediyl (C≦12) , alkynediyl (C≦12) , arenediyl (C≦12) , heteroarenediyl (C≦12) , alkoxydiyl (C≦12) , alkylaminodiyl (C≦12) , or a substituted version of any of these groups; or
an amino acid residue, an amino acid residue linked to a targeting moiety, a PEG linker comprising between 2 and 200 repeating units; and

provided that all of R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are not or a metal complex or salt thereof.

2. The compound of claim 1 , wherein the compound is further defined as:

or a metal complex or salt thereof.

Assignees

• Univ Texas
• Univ Texas

Inventors

• Sun Xiankai
• Kumar Amit
• Kovacs Zoltan

Classifications

• A61K49/0002

  General or multifunctional contrast agents, e.g. chelated agents · CPC title

• A61K51/065

  conjugates with carriers being macromolecules · CPC title

• A61K49/14 Primary

  Peptides, e.g. proteins · CPC title

• A61K49/124

  dendrimers, dendrons, hyperbranched compounds · CPC title

• A61K51/088

  conjugates with carriers being peptides, polyamino acids or proteins (antibodies A61K51/10) · CPC title