Fibrin sealant compositions with chemical crosslinking

Patent metadata

Field	Value
Publication number	US-9446166-B2
Application number	US-201313748678-A
Country	US
Kind code	B2
Filing date	Jan 24, 2013
Priority date	Jan 24, 2013
Publication date	Sep 20, 2016
Grant date	Sep 20, 2016

Abstract

The invention relates to tissue adhesives or sealants, more specifically to fibrinogen based sealants reinforced with particulate material and chemically cross-linked. More particularly, the present invention is directed to tissue sealant, adhesive, hemostat, or scaffolding material containing thrombin, fibrinogen, a biocompatible particulate material having amine functionality, and a biocompatible polymer containing aldehyde groups. The present invention is also directed to methods for the use of such materials.

First claim

I claim:

1. A tissue sealant, adhesive, hemostat, or scaffolding material, wherein said tissue sealant, adhesive, hemostat, or scaffolding material is a two-part system comprising a first solution and a second solution, comprising:
thrombin, fibrinogen, a biocompatible particulate material having amine functionality, said biocompatible particulate material is atelocollagen
a biocompatible polymer containing aldehyde groups, wherein said biocompatible polymer is oxidized dextran or polyvinyl alcohol acetoacetate; and a catalyst,
wherein said first solution comprises thrombin, biocompatible particulate material, and the biocompatible polymer;
wherein said second solution comprises fibrinogen and the catalyst; and wherein said catalyst is DABCO.

2. The tissue sealant, adhesive, hemostat, or scaffolding material of claim 1 , wherein the biocompatible polymer containing aldehyde groups is oxidized dextran.

3. The tissue sealant, adhesive, hemostat, or scaffolding material of claim 2 ,
wherein the biocompatible particulate material is atelocollagen, and
wherein the biocompatible polymer containing aldehyde groups is oxidized dextran.

4. The tissue sealant, adhesive, hemostat, or scaffolding material of claim 3 ,
wherein said first solution comprises thrombin, atelocollagen, and oxidized dextran and
wherein said second solution comprises fibrinogen and DABCO.

5. The tissue sealant, adhesive, hemostat, or scaffolding material of claim 4 ,
wherein concentration of atelocollagen is about 2%;
particle size of atelocollagen is less than 100 micron;
concentration of oxidized dextran is about 10% by volume,
and the molecular weight of oxidized dextran is between about 10,000 and 100,000.

6. The tissue sealant, adhesive, hemostat, or scaffolding material of claim 5 , wherein said first solution and said second solution are sprayed substantially simultaneously or sequentially on the tissue to form sealant, adhesive, hemostat, or scaffolding.

Assignees

• Ethicon Inc

Inventors

• Khatri Chetan Anirudh

Classifications

• A61L24/0094 Primary

  containing macromolecular fillers · CPC title

• C08L5/02

  Dextran; Derivatives thereof · CPC title

• C08L89/00

  Compositions of proteins; Compositions of derivatives thereof (foodstuff preparations A23J3/00) · CPC title

• C08L89/06

  derived from leather or skin {, e.g. gelatin} · CPC title

• C08L5/08

  Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof · CPC title