System for use in bone cement preparation and delivery

Patent metadata

Field	Value
Publication number	US-10039584-B2
Application number	US-201514932714-A
Country	US
Kind code	B2
Filing date	Nov 4, 2015
Priority date	Apr 21, 2008
Publication date	Aug 7, 2018
Grant date	Aug 7, 2018

Abstract

A system for use in combining two part preparations, such as bone cement, can include a chamber for intermixing liquid and powder components, a container, a vacuum channel, and a filter. The mixing chamber can be configured to hold a non-liquid, polymer powder component of a bone cement. The container can be configured to hold a liquid component of the bone cement. The vacuum channel can direct a partial vacuum to draw the liquid component from the container into the non-liquid component in the mixing chamber to intermix the components and to thereby provide a settable bone cement.

First claim

What is claimed is:

1. A method of preparing a bone cement, comprising:
forming a mixture of a monomer liquid and polymer beads in a chamber having an opening at one end and a porous member at another end;
applying a pressure to the mixture to mix the monomer liquid and the polymer beads, wherein applying the pressure comprises using a pressure applicator to remove air from the mixture through the porous member, wherein the pressure applicator comprises a syringe comprising a plunger configured to apply the pressure upon being displaced, the syringe further comprising a spring configured to resist being displaced; and
determining a level of mixing between the monomer liquid and the polymer beads by detecting a level of saturation of the porous member by the monomer liquid.

2. The method of claim 1 , wherein determining the level of mixing comprises detecting that the porous member is fully saturated with the monomer liquid that has been in contact with the polymer beads.

3. The method of claim 1 , wherein the porous member is configured to pass air therethrough and to selectively prevent the monomer liquid that has been in contact with the polymer beads and having a viscosity greater than a predetermined value from passing therethrough.

4. The method of claim 3 , wherein the polymer beads and the monomer liquid are configured such that the monomer liquid attains a viscosity exceeding the predetermined value upon the polymer bead surfaces being substantially saturated with the monomer liquid, and wherein the method further comprises determining that the polymer bead surfaces are substantially saturated with the monomer liquid based on air being removed from the mixture while the contacted monomer liquid is prevented from passing through the porous member.

5. The method of claim 1 , further comprising, after applying the pressure, allowing a mechanical equilibrium to be reached between a force exerted on the plunger by a pressurized mixture and an opposing spring force exerted on the plunger by the spring, and determining from the equilibrium that the porous member has been fully saturated.

6. The method of claim 1 , wherein the chamber and the pressure applicator are fixed in an upright position and extend in a vertical direction.

7. The method of claim 1 , wherein the chamber is at least partially formed of a transparent material such that determining the level of mixing comprises visually detecting the level of saturation of the porous member.

8. The method of claim 1 , wherein the porous member has a mean pore dimension of about 0.05 to 10 microns.

9. A method of preparing a bone cement, comprising:
providing a bone cement preparation system comprising a chamber configured to pass air therethrough and to selectively prevent a monomer liquid that has been in contact with polymer beads from passing therethrough;
applying a pressure to remove air from the chamber and into a flow channel;
expelling the air from the flow channel through a one-way valve;
mixing polymer beads and a monomer liquid in the chamber; and
determining that the polymer bead surfaces are substantially saturated with the monomer liquid based on air being removed from the mixture while the monomer liquid that has been in contact with the polymer beads is prevented from passing through the chamber.

10. The method of claim 9 , wherein the chamber is formed of a transparent material and determining that the polymer bead surfaces are substantially saturated comprises visually observing that the monomer liquid that has been in contact with the polymer beads is prevented from passing through the chamber.

11. The method of claim 9 , wherein the chamber comprises a porous member at a bottom end of the chamber that is configured to pass air and to selectively prevent the monomer liquid that has been in contact with polymer beads from passing through.

12. The method of claim 11 , further comprising determining a level of mixing between the monomer liquid and the polymer beads by detecting a level of saturation of the porous member.

13. The method of claim 12 , wherein determining the level of mixing comprises detecting that the porous member is fully saturated with the monomer liquid.

14. The method of claim 9 , wherein the polymer beads include a first volume of PMMA beads having an average cross section of less than about 100 microns and a second volume of PMMA beads having an average cross section of greater than about 100 microns.

15. The method of claim 14 , wherein the polymer beads have less than 2.5 weight percent of an initiator on the basis of the total weight of the polymer beads.

16. The method of claim 15 , wherein an initial volume ratio of the polymer beads to the monomer liquid is between 2:1 and 5:1.

17. The method of claim 9 , wherein applying the pressure comprises applying a negative pressure to the chamber.

18. The method of claim 9 , wherein applying the pressure comprises using a pressure source coupled to the chamber through a porous member.

19. The method of claim 18 , wherein the pressure source comprises a syringe having a retractable plunger.

20. The method of claim 19 , wherein detecting that the polymer bead surfaces are substantially saturated comprises detecting a change in position of the retractable plunger after applying the pressure.

21. A method of preparing a bone cement, comprising:
forming a mixture of a monomer liquid and polymer beads in a chamber having an opening at one end and a porous member at another end;
applying a pressure to the mixture to mix the monomer liquid and the polymer beads, wherein applying the pressure comprises using a pressure applicator to remove air from the mixture through the porous member, wherein the chamber and the pressure applicator are fixed in an upright position and extend in a vertical direction
wherein the pressure applicator comprises a syringe comprising a plunger configured to apply the pressure upon being displaced, the syringe further comprising a spring configured to resist being displaced.

Assignees

• Dfine Inc

Inventors

• Phan Christopher U
• Kohm Andrew

Classifications

• A61B17/8827

  with filtering, degassing, venting or pressure relief means · CPC title

• A61B17/8822

  characterised by means facilitating expulsion of fluid from the introducer, e.g. a screw pump plunger, hydraulic force transmissions, application of vibrations or a vacuum · CPC title

• A61B17/8805

  for introducing fluid filler into bone or extracting it (A61B17/7097, A61B17/8833 take precedence) · CPC title

• A61B2017/8838

  for mixing bone cement or fluid fillers · CPC title

• A61L24/0094

  containing macromolecular fillers · CPC title