Medical devices having particle-containing regions with diamond-like coatings

Patent metadata

Field	Value
Publication number	US-9440003-B2
Application number	US-26686205-A
Country	US
Kind code	B2
Filing date	Nov 4, 2005
Priority date	Nov 4, 2005
Publication date	Sep 13, 2016
Grant date	Sep 13, 2016

Abstract

According to an aspect of the present invention, various medical devices, including implantable or insertable medical devices, are provided, which comprise at least one particle-containing region whose surface is at least partially coated with a diamond-like coating.

First claim

The invention claimed is:

1. A medical device comprising:
(a) a polymer or metal substrate;
(b) a particle-containing region on the substrate that forms a layer, said layer comprising particles of one or more materials or particulate forms, said layer including a layer surface, and the particles being particulates having a minimum dimension of at least 0.5 nm and a maximum dimension of 1000 microns or less and comprising carbon particulates,
(c) said layer being a component of an mechanical actuator system that is configured to electrochemically generate bubbles within the particle-containing region when a voltage is applied, said system further comprising an electrolyte in said particle-containing region, a pair of electrodes and a separator, and
(d) a porous diamond-like coating layer on the surface of said particle-containing region.

2. The medical device of claim 1 , wherein the said particle-containing region comprises carbon nanotubes.

3. The medical device of claim 1 , wherein the said particle-containing region comprises single wall carbon nanotubes.

4. The medical device of claim 1 , wherein said particle-containing region is formed as a said layer on said substrate from a liquid suspension of carbon-particles.

5. The medical device of claim 1 , wherein said particle-containing region is formed as a said layer from two or more sheets, each comprising carbon-particles.

6. The medical device of claim 1 , wherein the said particle-containing region is from 1 to 100 μm in thickness.

7. The medical device of claim 1 wherein said device comprises a plurality of layers comprising carbon particles.

8. The medical device of claim 1 , wherein said diamond-like coating is a diamond-like carbon coating.

9. The medical device of claim 8 , wherein said diamond-like carbon coating contains an sp 3 fraction ranging from 60% to 95%.

10. The medical device of claim 8 , wherein said diamond-like carbon coating is formed by a pulsed laser deposition technique.

11. The medical device of claim 8 , wherein said diamond-like carbon coating ranges from 50 to 100 nm in thickness.

12. The medical device of claim 1 , wherein said particle-containing region has a second diamond-like coating layer on an inner surface thereof and said separator comprises said second diamond-like coating.

13. The medical device of claim 1 , wherein said device includes a therapeutic agent disposed beneath or within said particle-containing region.

14. The medical device of claim 13 , wherein said therapeutic agent selected from anti-thrombotic agents, anti-proliferative agents, anti-inflammatory agents, anti-migratory agents, agents affecting extracellular matrix production and organization, antineoplastic agents, anti-mitotic agents, anesthetic agents, anti-coagulants, vascular cell growth promoters, vascular cell growth inhibitors, cholesterol-lowering agents, vasodilating agents, agents that interfere with endogenous vasoactive mechanisms, and combinations thereof.

15. The medical device of claim 1 , wherein at least a portion of said medical device is configured for implantation or insertion into a vertebrate subject.

16. The medical device of claim 1 , wherein said medical device is selected from a guide wire, a balloon, a vena cava filter, a catheter, a stent, a stent graft, a vascular graft, a cerebral aneurysm filler coil, a myocardial plug, a heart valve, a vascular valve, and a tissue engineering scaffold.

17. The medical device of claim 1 , wherein the said particle-containing region is a conductive region.

18. The medical device of claim 17 , wherein the said particle-containing region has a conductivity that ranges from 1×10 4 to 1×10 6 S/m.

19. The medical device of claim 17 , further comprising, a second conductive region, and a therapeutic-agent-containing region comprising a charged therapeutic agent disposed between said second conductive region and said conductive particle containing region, wherein said device is configured to apply a voltage from said power source between said second conductive region and said conductive particle containing region.

20. The medical device of claim 19 , wherein said second conductive region is a conductive substrate corresponding to a medical device or a portion thereof.

21. The medical device of claim 1 wherein the diamond-like coating has a hardness in the range of about 10 GPa to about 90 GPa.

22. The medical device of claim 1 wherein the diamond-like coating has a hardness of about 49 GPa or more.

23. The medical device of claim 1 wherein the particles in said layer have a maximum dimension of at least 100 nm.

24. The medical device of claim 1 wherein the particles in said layer have a minimum dimension of 10 micrometers or less.

25. The medical device of claim 1 wherein said medical device is an expandable medical device.

Assignees

• Weber Jan
• Boston Scient Scimed Inc

Inventors

• Weber Jan

Classifications

• A61L2400/12

  Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces · CPC title

• A61L29/103

  Carbon · CPC title

• A61L31/084

  Carbon; Graphite · CPC title

• B82Y30/00

  Nanotechnology for materials or surface science, e.g. nanocomposites · CPC title

• A61L27/303 Primary

  Carbon · CPC title