Method for treating a medical implant

Patent metadata

Field	Value
Publication number	US-2017304501-A1
Application number	US-201515510235-A
Country	US
Kind code	A1
Filing date	Oct 21, 2015
Priority date	Oct 23, 2014
Publication date	Oct 26, 2017
Grant date	—

Abstract

A method for treating a medical implant uses plasma polymerization to apply a coating At least one treatment parameter is selected so that the reactive chemical groups of the coating are chemically modified to prevent an adsorption of interfering substances into the coating. An implant includes a plasma polymer coating that is biocompatible, and includes a antibiotically acting metal. The coating is free from aldehyde groups

First claim

What is claimed is:

1 . A method for treating a medical implant, the method comprising the steps of:
placing the implant into a plasma reactor; and applying at least one coating to at least a portion of a surface of the implant by plasma polymerization in the presence of oxygen and at least one saturated hydrocarbon.

2 . The method according claim 1 , wherein said applying is carried out in the presence of at least one saturated hydrocarbon selected from the group consisting of saturated C1 to C6 hydrocarbons.

3 . The method according to claim 1 , wherein the coating is treated with at least one reducing agent selected from the group consisting of sodium borohydride, tris(hydroxymethyl)aminomethane (TRIS), ethanolamine and glycine.

4 . The method according to claim 1 , wherein said applying is conducted with coating parameters of 1 pascal (Pa) to 10 Pa, flow rate of oxygen and at least one saturated hydrocarbon: 0 standard cubic centimeters per minute (sccm) to 10 sccm, current intensity of the plasma polymerization system: 100 milliamperes (mA) to 500 mA.

5 . The method according to claim 1 , wherein the plasma polymerization is carried out in the presence of a metal, which is thereby partially incorporated into the coating.

6 . The method according to claim 5 , wherein the metal is selected from the group consisting of titanium, silver, copper, zinc, mercury, tin, lead, bismuth, cadmium, chromium, and thallium, and the alloys thereof.

7 . The method according to claim 1 , wherein said applying is conducted in the presence of methane using the following coating parameters: pressure: 5 Pa, flow rate of the methane coating gas: 2.5 sccm, flow rate of the oxygen coating gas: 1.3 sccm, current intensity of the plasma polymerization system: 200 mA, electrode of the plasma polymerization system: 100% titanium.

8 . The method according to claim 1 , further comprising sterilizing the coating on the surface of the implant.

9 . (canceled)

10 . The implant according to claim 11 , wherein the implant is selected from the group comprising or consisting of: a biosensor, a dialysis device, a drug delivery system, an electrode, a vascular sleeve, a pacemaker, a cardiac pacemaker, a defibrillator, a cardioverter, a brain pacemaker, a neuroprosthesis, electrodes/electronics for artificial extremities, a neurostimulator, a barostimulator, a kidney pacemaker, a duodenal pacemaker, a cardiac implant, a tumor monitoring implant, an artificial heart, an artificial heart valve, a shunt, a brain shunt, a hydrocephalus implant, a telemetry unit, a receiver, a transmitter, a pressure sensor, an organ substitute, an energy harvesting implant, a bio fuel cell, a catheter, a cochlear implant, a retinal implant, a dental implant, an artificial implantable lens system, an implant for joint replacement, a vascular prosthesis and a stent.

11 . An implant comprising a coating, the coating comprising carbon, nitrogen, oxygen and a metal, which is selected from the group consisting of titanium, silver, copper, zinc, mercury, tin, lead, bismuth, cadmium, chromium, and thallium, and the alloys thereof.

12 . The implant according to claim 11 , wherein the metal is titanium or a titanium alloy.

13 . The implant according to claim 11 , wherein the coating has a layer thickness of 1 nanometer (nm) to 200 nm.

14 . (canceled)

15 . The implant according to claim 11 , wherein the coating is free from aldehyde groups.

16 . An implant comprising a plasma polymer coating that is biocompatible and includes a antibiotically acting metal, wherein the coating is free from aldehyde groups.

Assignees

• Biotronik Se & Co Kg
• Albert-Ludwigs-Universitaet Freiburg

Inventors

• Bunge Andreas
• Bergmann Michael
• Ledernez Loic
• Horak Josef
• Urban Gerald

Classifications

• A61L31/125

  having a macromolecular matrix · CPC title

• A61L27/44 Primary

  having a macromolecular matrix · CPC title

• A61L27/34

  Macromolecular materials · CPC title

• A61L27/54

  Biologically active materials, e.g. therapeutic substances {(A61L27/227 takes precedence)} · CPC title

• A61L2420/02

  Methods for coating medical devices · CPC title