Controlled drug release from electrospun fibers
US-2018289813-A1 · Oct 11, 2018 · US
Polypeptide electrospun nanofibrils of defined composition
US9428849B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9428849-B2 |
| Application number | US-201113704867-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jun 21, 2011 |
| Priority date | Jun 21, 2010 |
| Publication date | Aug 30, 2016 |
| Grant date | Aug 30, 2016 |
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- Title
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Abstract
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Electrospun nanofibrils and methods of preparing the same are provided. The electrospun nanofibrils comprise at least one polypeptide. A polypeptide can be dissolved in a solution, and the solution can be electrospun into a nanofibril. The solution can be added to a syringe or syringe pump, and an electric field can be applied to electrospin the at least one polypeptide.
First claim
Opening claim text (preview).
We claim: 1. An electrospun nanofibril, comprising a polypeptide that is poly(L-glutamate, tyrosine), wherein the polypeptide satisfies the following equation: (non-polar surface area−polar surface area)/DP<100 square angstroms/residue, where DP is the degree of polymerization of the polypeptide. 2. The electrospun nanofibril according to claim 1 , wherein the polypeptide satisfies the opposite charges criterion. 3. The electrospun nanofibril according to claim 2 , wherein the degree of polymerization of the polypeptide is at least 25. 4. The electrospun nanofibril according to claim 1 , wherein a diameter of the nanofibril is less than a micron. 5. The electrospun nanofibril according to claim 2 , wherein a diameter of the nanofibril is less than a micron. 6. The electrospun nanofibril according to claim 3 , wherein a diameter of the nanofibril is less than a micron.
Assignees
Inventors
Classifications
- D01F6/68Primary
from polyaminoacids or polypeptides · CPC title
the fibre formed by solvent evaporation, i.e. dry electro-spinning · CPC title
Polyamides derived from alpha-amino carboxylic acids (C08L77/10 takes precedence) · CPC title
Alpha-amino-carboxylic acids {(polysuccinimides C08G73/1092)} · CPC title
characterised by the fineness · CPC title
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Frequently asked questions
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- What does patent US9428849B2 cover?
- Electrospun nanofibrils and methods of preparing the same are provided. The electrospun nanofibrils comprise at least one polypeptide. A polypeptide can be dissolved in a solution, and the solution can be electrospun into a nanofibril. The solution can be added to a syringe or syringe pump, and an electric field can be applied to electrospin the at least one polypeptide.
- Who is the assignee on this patent?
- Haynie Donald T, Zhai Lei, Univ South Florida, and 1 more
- What technology area does this patent fall under?
- Primary CPC classification D01F6/68. Mapped technology areas include Textiles & Paper.
- When was this patent published?
- Publication date Tue Aug 30 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).