Peptide macrocycles against acinetobacter baumannii
US-2024050516-A1 · Feb 15, 2024 · US
US9415114B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9415114-B2 |
| Application number | US-201514805588-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jul 22, 2015 |
| Priority date | Apr 21, 2011 |
| Publication date | Aug 16, 2016 |
| Grant date | Aug 16, 2016 |
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A series of peptides with divergent confirmations including structures of formula (1A), (1B), (2) and (3) are provided. In the formula, wherein U, G, A, B, R1, R2 and T are as defined in the specification. The divergent peptides disclosed in the present invention are characterized in a mineral binding affinity function.
Opening claim text (preview).
What is claimed is: 1. A pharmaceutical composition, comprising a pharmaceutically acceptable carrier and an effective amount of a compound having a formula 3: wherein R1 is -(Asp-)K, R2 is one selected from a group consisting of a polyamindoamine dendrimer (PAMAM), a polyester type dendrimer, a polyglycerol dendrimer, a triazine based dendrimer, a poly(propyleneimine)dendrimer and a Newkome-type dendrimer, where 64≧T≧1, 20≧K≧1, where T and K are natural numbers, Asp represents an aspartic acid, and Gly represents a glycine. 2. A divergent compound, comprising a structure having a formula 3: wherein R1 is -(Asp-)K, R2 is one selected from a group consisting of a polyamindoamine dendrimer (PAMAM), a polyester type dendrimer, a polyglycerol dendrimer, a triazine based dendrimer, a poly(propyleneimine)dendrimer and a Newkome-type dendrimer, where 64≧T≧1, 20≧K≧1, T and K are natural numbers, Asp represents an aspartic acid, and Gly represents a glycine. 3. A divergent compound as claimed in claim 2 , wherein R2 is a polyamindoamine dendrimer (PAMAM).
with the first amino acid being basic · CPC title
Polymers modified by chemical after-treatment · CPC title
Polyamidoamines · CPC title
Human Necessities · mapped topic
Tripeptides · CPC title
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